2012 Fiscal Year Final Research Report
Histone modification change of Juvenile myelomonocytic leukemia (JMML) and establishment of JMML stem cell expansion system
| Project/Area Number |
22591154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOIKE Kenich 信州大学, 医学部, 教授 (40143979)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 若年性骨髄単球性白血病 / 白血病幹細胞 / ヒストン修飾 |
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| Research Abstract |
We established the JMML CD34+CD38- cell expansion system. This method may be useful for the development of a new therapeutic method for leukemia stem cells in JMML.And we demonstrated that histone acethyltransferase inhibitor may be useful for JMML treatment.
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