2012 Fiscal Year Final Research Report
Elucidation of the pathogenesis of Langerhans cell histiocytosis from the point of bone immunology
| Project/Area Number |
22591167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Sachie 自治医科大学, 医学部, 助教 (20382955)
HAYASE Tomomi 自治医科大学, 医学部, 助教 (50433587)
HAYAKAWA Takahiro 自治医科大学, 医学部, 大学院生 (60458312)
OH Yukiko 自治医科大学, 医学部, 大学院生 (30438650)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児血液学 |
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| Research Abstract |
LCH cells have characteristics of immature dendritic cell (iDC), which differentiate into osteoclasts in inflammatory environment. Osteopontin has been known as a proinflammatory cytokine, which is involved in bone resorption by osteoclasts. Here we show
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Research Products
(27 results)
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[Journal Article] IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy.2013
Author(s)
Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T
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Journal Title
Virchows Arch.
Volume: 462
Pages: 219-228
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[Journal Article] Therapeutic outcome of multifocal Langerhans cell histiocytosis in adults treated with the Special C regimen t formulated by the Japan LCH Study Group2013
Author(s)
Morimoto A, Shimazaki C, Takahashi S, Yoshikawa K, Nishimura R, Wakita H, Kobayashi Y, Kanegane H, Tojo A, Imamura T, Imashuku S.
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Journal Title
Int J Hematol.
Volume: 97
Pages: 103-108
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[Journal Article] for the LCH Committee, the Japanese Pediatric Leukemia/Lymphoma Study Group. Nationwide Survey of Bisphosphonate Therapy for Children with Reactivated Langerhans Cell Histiocytosis in Japan2011
Author(s)
Morimoto A, Shioda Y, Imamura T, Kanegane H, Sato T, Kudo K, Nakagawa S, Nakadate H, Tauchi H, Hama A, Yasui M, Nagatoshi Y, Kinoshita A, Miyaji R, Anan T, Yabe M, Kamizono J
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Journal Title
Pediatr Blood Cancer
Volume: 56
Pages: 110-115
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[Presentation] Intensified and prolonged therapy improved the outcome in multi-system Langerhans cell histiocytosis.2012
Author(s)
Morimoto A, Shioda Y, Imamura T, Kudo K, Sato T, Shiohara M, Yasui M, Koga Y, Kobayashi R, Ishii E, Fujimoto J, Horibe K, Bessho F, Tsunematsu Y, Imashuku S
Organizer
28th Annual Meeting of the Histiocyte Society.
Place of Presentation
London UK
Year and Date
20121000
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[Presentation] Multifocal LCH in adult patients treated with special C regimen of JLSG-02 protocol2011
Author(s)
Morimoto A, Shimazaki C, Takahashi S, Yoshikawa K, Kuroda R, Wakiya H, Kobayashi H, Kanegane H, Akiyama S, Tojyo A, Imamura T, Imashuku S.
Organizer
27th Annual Meeting of the Histiocyte Society.
Place of Presentation
Vienna Austria
Year and Date
20111000
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