2012 Fiscal Year Final Research Report
Analysis of Human Regenerated Bone Marrow and Hematopoietic StemCell/Leukemic Stem Cell Niche
| Project/Area Number |
22591169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
UEDA Takahiro 日本医科大学, 医学部, 講師 (20322505)
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| Co-Investigator(Kenkyū-buntansha) |
MIGITA Makoto 日本医科大学, 医学部, 准教授 (50256963)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児血液学 |
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| Research Abstract |
Regenerated bone marrow prepared using human mesenchymal cells have the ability to provide a bone marrow niche because long-term maintenance of human hematopoietic cells under the skin of the NOD mouse, an immune-deficient mouse, is possible. On the other hand, a function analysis of regenerated bone marrow prepared from adipose-derived stromal cells of mice revealed that this regenerated bone marrow can provide an environment (bone marrow niche) that is capable of maintaining the ability to self-renew as well as the multilineage potential of hematopoietic cells.
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