2012 Fiscal Year Final Research Report
STUDY OF MINIMAL RESIDUAL DISEASE MEASUREMENTS AND CLINICAL APPLICATION IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA
| Project/Area Number |
22591170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HORI Toshinori 愛知医科大学, 医学部, 准教授 (20308943)
HORIBE Keizou 独立行政法人国立病院機構名古屋医療センター, 臨床研究センター, センター 長 (30209308)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児白血病 / 微小残存病変 / 免疫関連遺伝子再構成 / 再発白血病 |
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| Research Abstract |
In order to improve PCR-based MRD diagnostics using IgG/TCR genes in childhood ALL, we have measured MRD levels of bone marrow samples obtained from 100-150 patients/year with ALL, and we achieved a high frequency and sensitivities of Ig and TCR gene rearrangements as MRD PCR targets in childhood ALL. Our next study isto clarify the clinical implication of MRD levels in patients with relapsed ALL.
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[Journal Article] Flow cytometric analysis of de novo acute lymphoblastic leukemia in childhood: report from the Japanese Pediatric Leukemia/Lymphoma Study Group.2011
Author(s)
Iwamoto S, Deguchi T, Ohta H, KiyokawaN, Tsurusawa M, Yamada T, Takase K, Fujimoto J, Hanada R, Hori H, HoribeK, Komada Y.
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Journal Title
Int JHematol
Volume: 94
Pages: 185-192
Peer Reviewed
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[Journal Article] Japanese Childhood Cancer and Leukemia Study Group (JCCLSG). Assessment of late cardiotoxicity of pirarubicin (THP) in children with acute lymphoblastic leukemia.2011
Author(s)
Shimomura Y, Baba R, Watanabe A, Horikoshi Y, Asami K, Hyakuna N, Iwai A, Matsushita T, Yamaji K, Hori T,Tsurusawa M;
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Journal Title
Pediatr Blood Cancer
Volume: 57
Pages: 461-466
Peer Reviewed
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[Journal Article] Japanese Childhood Cancer Leukemia Study Group. Minimal residualdisease-based augmented therapy in childhood acute lymphoblastic leukemia: a report from the Japanese Childhood Cancer and Leukemia Study Group.2010
Author(s)
Yamaji K, Okamoto T, Yokota S, WatanabeA, Horikoshi Y, Asami K, Kikuta A, Hyakuna N, Saikawa Y, Ueyama J, Watanabe T, Okada M, Taga T, Kanegane H, Kogawa K, Chin M, Iwai A, Matsushita T, Shimomura Y, Hori T, Tsurusawa M;
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Journal Title
Pediatr Blood Cancer.
Volume: 55
Pages: 1287-1295
Peer Reviewed
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[Journal Article] Japanese Childhood Cancer and Leukemia Study Group. Long-term results of the Japanese childhood cancer and leukemia study group studies 811, 841, 874, and 911 onchildhood acute lymphoblastic leukemia.2010
Author(s)
Tsurusawa M, Shimomura Y, Asami K, Kikuta A, Watanabe A, Horikoshi Y, Matsushita T, Kanegane H, Ohta S, IwaiA, Mugishima H, Koizumi S;
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Journal Title
Leukemi
Volume: 24
Pages: 335-344
Peer Reviewed
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