2012 Fiscal Year Final Research Report
Implication of the expression of retinoic acid-inducible gene-I in human glomerulonephritis
| Project/Area Number |
22591175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAIZUMI Tadaatsu 弘前大学, 大学院・医学研究科, 教授 (90232602)
YOSHIDA Hidemi 弘前大学, 大学院・医学研究科, 講師 (40201008)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児腎 / 泌尿器科学 |
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| Research Abstract |
Viral infections may trigger the development of inflammatory renal disease or the worsening of pre-existing renal disease. Viral double-stranded RNA (dsRNA) can activate not only toll-like receptors (TLR) 3 located within intracellular endosomes and retinoic acid-inducible gene-I (RIG-I)-like helicase receptors located within the cytosol. RIG-I and melanoma differentiation-associated gene-5 (MDA5) are members of the RNA helicase family in the cytosol, and both act as pathogen recognition receptors. The activation of TLRs and their downstream immune responses can be induced by both infectious pathogens and non-infectious stimuli such as endogenous ligands, and this mechanism may be involved in the pathogenesis of autoimmune renal diseases. Based on our recent experimental studies using cultured normal human mesangial cells (MCs), we found that novel TLR3/RIG-I-mediated signaling pathways in MCs may be involved in the pathogenesis of glomerular diseases.
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[Journal Article] IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells2010
Author(s)
Imaizumi T, Tanaka H, Tajima A, Yokono Y, Matsumiya T, Yoshida H, Tsuruga K, Aizawa-Yashiro T, Inoue I, Ito E, Satoh K
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Journal Title
Am J Nephrol
Volume: 32
Pages: 462-468
Peer Reviewed
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