The role of thioredoxin-1 administration to severe influenza A virus infection.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Okayama University
• Principal Investigator: YAMASHITA Nobuko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40379798)
• Co-Investigator(Kenkyū-buntansha): TSUKAHARA Hirokazu 岡山大学, 大学院・医歯薬学総合研究, 准教授 (90207340)
• Project Period (FY): 2010 – 2012
• Keywords: インフルエンザ / チオレドキシン / レドックス

Research Abstract

Extragenous preventive administration of recombinant human thioredixin-1 significantly improved the survival rate and attenuated lung histological change in the murine model of influenza pneumonia.

Research Products

• [Journal Article] Redox-active prote administration ameliorates influenza(H1N1)-induced acute lung injury in mice. (2013)
  • Author(s): Yashiro M, Tsukahara H, Matsukawa A, Yamada M, Fujii Y, Nagaoka Y, Tsuge M, Yamashita N, Ito T, Yamada M, Masutani H, Yodoi J, Morishima T
  • Journal Title: CCare Med Volume: 41(1) Pages: 171-181
  • Peer Reviewed