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2012 Fiscal Year Final Research Report

Pathophysiology and pharmacotherapy in pulmpnary arterial hypertension

Research Project

  • PDF
Project/Area Number 22591180
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionThe University of Tokushima

Principal Investigator

HAYABUCHI Yasunobu  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (20403686)

Co-Investigator(Kenkyū-buntansha) SAKATA Miho  徳島大学, 病院, 特任助教 (80532514)
Project Period (FY) 2010 – 2012
Keywords肺高血圧 / 血管平滑筋細胞 / イオンチャネル / カリウムチャネル
Research Abstract

Proliferative smooth muscle cells predominantly express intermediate-conductance Ca2+-activated K+ (IKca) channels.This phenotypic shift in the Kca channel expression pattern gives rise to dramatic alterations in the electrical properties of the cell, which have functional consequences, inpart because of the effect on Ca2+ influx. IKca channel activation contributes to Ca2+ entry in smooth muscle cells andtherefore affect migration and proliferation in some pathophysiologic conditions.

  • Research Products

    (15 results)

All 2013 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Complete but not partial thymectomy in early infancy reduces T-cell-mediated immune response: three-year tracing study after pediatric cardiac surgery2013

    • Author(s)
      Kurobe H, Tominaga T, Sugano M, Hayabuchi Y, Egawa Y, Takahama Y, Kitagawa T
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 143 Pages: 656-662

    • DOI

      doi:10.1016/j.jtcvs.2012.12.015

    • Peer Reviewed
  • [Journal Article] Ratio of Early Diastolic Tricuspid Inflow to Tricuspid Lateral Annulus Velocity Reflects Pulmonary Regurgitation Severity but Not Right Ventricular Diastolic Function in Children With Repaired Tetralogy of Fallot2013

    • Author(s)
      Hayabuchi Y, Sakata M, Ohnishi T, Inoue M, Kagami S
    • Journal Title

      Pediatric Cardiology

      Volume: 34 Pages: 1112-1117

    • DOI

      doi:10.1007/s00246-012-0612-1

    • Peer Reviewed
  • [Journal Article] Left Atrial Volume Change Throughout the Cardiac Cycle in Children With Congenital Heart Disease Associated With Increased Pulmonary Blood Flow : Evaluation Using a Novel Left Atrium-Tracking Method2013

    • Author(s)
      Sakata M, Hayabuchi Y, Inoue M, Onishi T, Kagami S
    • Journal Title

      Pediatric Cardiology

      Volume: 34 Pages: 105-111

    • DOI

      doi:10.1007/s00246-012-0395-4

    • Peer Reviewed
  • [Journal Article] Subclavian and pulmonary artery steal phenomenon in a patient with isolated left subclavian artery and right aortic arch2013

    • Author(s)
      Hayabuchi Y, Inoue M, Sakata M, Ohnishi T, Kagami S
    • Journal Title

      J Clin Ultrasound

      Volume: 41 Pages: 265-268

    • DOI

      doi:10.1002/jcu.21874

    • Peer Reviewed
  • [Journal Article] Multidetector-row computed tomography evaluation of bilateral bronchial narrowing associated with increased pulmonary blood flow in children with congenital heart disease2012

    • Author(s)
      Watanabe N, Hayabuchi Y, Nakagawa R, Saijo T, Kagami S
    • Journal Title

      Congenital Heart Disease

      Volume: 7 Pages: 410-416

    • DOI

      doi:10.1111/j.1747-0803.2012. 00653.x

    • Peer Reviewed
  • [Journal Article] A novel bilayer approach to ventricular septal deformation analysis by speckle tracking imaging in children with right ventricular overload2011

    • Author(s)
      Hayabuchi Y, Sakata M, Ohnishi T, Kagami S
    • Journal Title

      J Am Soc Echocardiogr

      Volume: 24 Pages: 1205-1212

    • DOI

      doi:10.1016/j.echo.2011.06. 016.

    • Peer Reviewed
  • [Journal Article] Serum concentration of heart-type fatty acid-binding protein in children and adolescents with congenital heart disease2011

    • Author(s)
      Hayabuchi Y, Inoue M, Watanabe N, Sakata M, Ohnishi T, Kagami S
    • Journal Title

      Circ J

      Volume: 75 Pages: 1992-1997

    • DOI

      doi:10.1253/circj.CJ-10-1256

    • Peer Reviewed
  • [Journal Article] Cell membrane stretch activates intermediate- conductance Ca2+-activated K+ channels in arterial smooth muscle cells2011

    • Author(s)
      Hayabuchi Y, Nakaya Y, Mawatari K, Inoue M, Sakata M, Kagami S
    • Journal Title

      Heart Vessels

      Volume: 26 Pages: 91-100

    • DOI

      doi:10.1007/s00380-010-0025-0

    • Peer Reviewed
  • [Journal Article] Minimum-intensity projection of multidetector-row computed tomography for assessment of pulmonary hypertension in children with congenital heart disease2011

    • Author(s)
      Hayabuchi Y, Inoue M, Watanabe N, Sakata M, Nabo MM, Kagami S
    • Journal Title

      Int J Cardiol

      Volume: 149 Pages: 192-198

    • DOI

      doi:10.1016/j.ijcard.2010.01.008.

    • Peer Reviewed
  • [Journal Article] Multidetector-row computed tomography visualized peripheral pulmonary artery patency in a patient with occluded modified Blalock-Taussig shunt2011

    • Author(s)
      Hayabuchi Y, Inoue M, Sakata M, Kagami S
    • Journal Title

      Int J Cardiol

      Volume: 15 Pages: e57-58

    • DOI

      doi:10.1016/j.ijcard.2009.10.010

    • Peer Reviewed
  • [Journal Article] Coronary arteriovenous fistula: direct connection of the proximal circumflex artery to the coronary sinus2010

    • Author(s)
      Hayabuchi Y
    • Journal Title

      Pediatric Cardiology

      Volume: 31 Pages: 168-169

    • DOI

      doi:10.1007/s00246-009-9555-6

    • Peer Reviewed
  • [Presentation] 心室中隔は2層に区分され、それらの asynchrony は心室中隔機能低下を惹起する2012

    • Author(s)
      早渕康信、阪田美穂,大西達也,渡辺典子,香美祥二
    • Organizer
      第48回日本小児循環器学会総会・学術集会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2012-07-05
  • [Presentation] Fontan 術後患者の肝機能障害・肝線維症に対するウルソデオキシコール酸の効果2012

    • Author(s)
      早渕康信,阪田美穂,大西達也,渡辺典子,香美祥二
    • Organizer
      第48回日本小児循環器学会総会・学術集会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2012-07-05
  • [Presentation] Dual Dopller 法を用いた拡張早期左室流入血流と僧帽弁輪運動の時相解析による左室拡張障害診断2012

    • Author(s)
      阪田美穂,早渕康信,大西達也,香美祥二
    • Organizer
      第48回日本小児循環器学会総会・学術集会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2012-07-05
  • [Book] Springer, Mechanosensitivity in Cells and Tissues. Vol.6 Mechanically gated channels and their regulation2012

    • Author(s)
      Hayabuchi Y, Sakata M, Ohnishi T, Kagami S
    • Total Pages
      159-188

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Published: 2014-08-29   Modified: 2015-10-15  

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