2012 Fiscal Year Final Research Report
An investigation and its control of the novel influenza virus replication mechanism using human upper respiratory airway model
| Project/Area Number |
22591187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SATO Masatoki 福島県立医科大学, 医学部, 講師 (60423795)
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| Co-Investigator(Kenkyū-buntansha) |
光亮 Mitsuaki 福島県立医科大学, 医学部, 教授 (80192318)
HASHIMOTO Kouichi 福島県立医科大学, 医学部, 准教授 (50322342)
OHARA Shinichiro 福島県立医科大学, 医学部, 助教 (00566846)
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| Project Period (FY) |
2010 – 2012
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| Keywords | インフルエンザ / アポトーシス / プロテアーゼ |
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| Research Abstract |
Influenza viruses induce the cell death to the host cell after infection and the viruses replicated acquire their infectivity using the protease derived from the host cells. In this study, the relation between the cell death induced by influenza virus infection and its replication was studied. As one of results, the novel virus replication mechanism, influenza viruses exploit one of the proteases to acquire infectivity which is induced after infection and contribute to the cell death, is suggested.
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[Journal Article] Rhinovirus load and disease severity in children with lower respiratory tract infections.2012
Author(s)
Takeyama A, Hashimoto K, Sato M, Sato T, Kanno S, Takano K, Ito M, Katayose M, Nishimura H, Kawasaki Y, Hosoya M
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Journal Title
J Med Virol
Volume: 84
Pages: 1135-1142
DOI
Peer Reviewed
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