2012 Fiscal Year Final Research Report
Role of Ubiquitin specific protease 40 in Glomerulus
| Project/Area Number |
22591191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAN Kunimasa 杏林大学, 医学部, 教授 (70255389)
AKIMOTO Yosihiro 杏林大学, 医学部, 准教授 (60184115)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIGAKI Yasuhito 金沢医科大学, 医学部, 准教授 (20232275)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児腎 / 泌尿器学 |
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| Research Abstract |
Unbiased transcriptome profiling and functional genomics approaches identified USP40, a family of deubiquitinating enzyme, as being a transcript highly specific for the glomerulus. But its protein characterization and biologic function is not known at all. USP40 may stabilize HINT1 which is known to up-regurate cellular level of cycln-dependent kinase inhibitor p27kip1, by its ubiquitinating activity, thereby influencing the glomerular deveropmental process via modulating cell cycle system of glomerular endotherial cells and podocytes.
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Research Products
(3 results)
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[Presentation] (Department o Pediatrics,Anatomy, Pharmacology,Lab Membrane Biochemistry and Biophysics Graduate School of Biostudies, Kyoto University)Role of ubiquitin specific protease 40(USP40) in glomerular development.2012
Author(s)
Takagi H, Nishibori Y, Kiuchi Z, Ito Y, Kudo A, Akimoto Y, Kimura T, Takematsu H, Yan K
Organizer
The 4thEMBO meeting 2012
Place of Presentation
Nice
Year and Date
20120922-25
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