Morphology and Morphometry of the human embryos by magnetic resonance microscopic imaging

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591199
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kyoto University
• Principal Investigator: TAKAKUWA Tetsuya 京都大学, 大学院・医学研究科, 教授 (40244933)
• Co-Investigator(Kenkyū-buntansha): YAMADA Shigehito 京都大学, 大学院・医学研究科, 教授 (80432384)
• Project Period (FY): 2010 – 2012
• Keywords: 3次元画像 / MR顕微鏡 / ヒト胚子 / 形態形成 / 発生

Research Abstract

Insights into the dynamic and complex processes during organogenesis will require accurate morphologic data with dynamic modeling of embryonic structures. Especially, 3D reconstructions are necessary to elucidate the complex anatomic remodeling that occurs during these early embryonic stages. In this aspects, morphogenesis during early human embryonic periods, has been precisely analysed using the MR image data. Those embryo and materials derived from the “Kyoto Collection” which is the the largest collection of human embryo specimens in the world, stored at the Congenital Anomaly Research Center. The obtained data will contribute to a better understanding of morphogenesis of human embryo, and serve as a useful reference for fetal medicine and prenatal diagnosis.

Research Products

• [Journal Article] Morphogenesis of lateral choroid plexus during human embryonic period (2013)
  • Author(s): Shiraishi N, Nakashima T, Yamada S, Uwabe C, Kose K, Takakuwa T
  • Journal Title: Anat Rec (Hoboken) Volume: 296(4) Pages: 692-700
  • DOI: doi:10.1002/ar.22662
  • Peer Reviewed
• [Journal Article] Morphology and Morphometry of Fetal Liver at 16-26 Weeks of Gestation by Magnetic Resonance Imaging-Comparison with Embryonic Liver at Carnegie Stage 23 (2013)
  • Author(s): Hamabe Y, Hirose A, Yamada S, Uwabe C, Okada T, Togashi K, Kose K, Takakuwa T
  • Journal Title: Hepatol Res Volume: 43 Pages: 639-647
  • DOI: doi:10.1111/hepr.12000
  • Peer Reviewed
• [Journal Article] Morphometric analysis of the brain vesicles during the human embryonic period by magnetic resonance microscopic imaging (2012)
  • Author(s): Nakashima T, Hirose A, Yamada S, Uwabe C, Kose K, Takakuwa T
  • Journal Title: Congenit Anom (Kyoto) Volume: 52(1) Pages: 55-8
  • DOI: doi;10.1111/j.1741-4520.2011.00345.x
  • Peer Reviewed
• [Journal Article] Movement of the external ear in human embryo (2012)
  • Author(s): Kagurasho M, Yamada S, Uwabe C, Kose K, TakakuwaT
  • Journal Title: Head Face Med Volume: 8(1) Pages: 2
  • DOI: doi:10.1186/1746-160X-8-2
  • Peer Reviewed
• [Journal Article] Hirose A, Nakashima T, Yamada S, Uwabe C, Kose K, Takakuwa T (2012)
  • Author(s): Hirose A, Nakashima T, Yamada S, Uwabe C, Kose K, Takakuwa T
  • Journal Title: Anat Rec (Hoboken) Volume: 295(1) Pages: 51-9
  • DOI: doi;10.1002/ar.21496
  • Peer Reviewed
• [Journal Article] Morphogenesis and three-dimensional movement of the stomach during the human embryonic period
  • Author(s): Kaigai N, Nako A, Yamada S, Uwabe C, Kose K, Takakuwa T
  • Journal Title: Anat Rec (Hoboken) Volume: (in press)
  • Peer Reviewed
• [Journal Article] The layered structure of the articular surface
  • Author(s): Fujioka R, Aoyama T, Takakuwa T
  • Journal Title: Osteoarthritis Cartilage Volume: (in press)
  • DOI: doi:10.1016/j.joca.2013.04.021
  • Peer Reviewed
• [Book] the Human Embryo (2012)
  • Author(s): Yamada S, Takakuwa T
  • Total Pages: 180
  • Publisher: InTech -Open Access Publisher
• [Remarks] 京都大学医学研究科人間健康科学系専攻病理学研究室
  • URL: http://www.hs-kyoto.net/
• [Remarks] Kyoto Human Embryo Visualizing Project
  • URL: http://bird.cac.med.kyoto-u.ac.jp/index.html