2012 Fiscal Year Final Research Report
Evaluation of olfactory and taste development of premature infants by near-infrared spectroscopy
| Project/Area Number |
22591202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKA Takashi 香川大学, 医学部附属病院, 講師 (50274288)
YASUDA Saneyuki 香川大学, 医学部附属病院, 助教 (00380155)
KONISHI Yukihiko 香川大学, 医学部附属病院, 助教 (60528157)
IZICHI Sonoko 香川大学, 医学部, 助教 (70437680)
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| Project Period (FY) |
2010 – 2012
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| Keywords | NIRS / 早産児 / 嗅覚 / 味覚 / 光トポグラフィー |
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| Research Abstract |
Abstract: Preterm infants are raised in the unique environment of an incubator for a long period. This environment is considerably different from that of term infants, and thisdifference could have a great impact on their neurological development. We aimed tocompare brain developmental function in the olfactory cortex between preterm and term infants by using near-infrared spectroscopy (NIRS). We also aimed to elucidate the characteristics of development in the olfactory cortex. We chose term and preterm infants with corresponding postconceptional ages and used NIRS to determine the change of cerebral blood volume upon stimulation with the breast-milk odor of their own mothers, that of other mothers and formula odor. In term infants, upon odor stimulation by other mothers, there was a negative correlation between birth date and the latency of [oxyHb] in response to odor simulation (latency). In contrast, upon odor stimulation by theirown mothers, there was a positive correlation between birth date and latency. In preterm infants, upon odor stimulation by formula, there was a negative correlation between birth date and latency. Comparing the latency between preterm and term infants adjusted for birth week, there were no significant differences with any type of stimulation.
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[Journal Article] Extrauterine environment influences spontaneous low-frequency oscillations in the preterm brain2013
Author(s)
Kato I, Kusaka T, Nishida T, Koyano K, Nakamura S, Nakamura M, Konishi Y, Kunikata J, Jinnai W, Yasuda S, Okada H, Itoh S, Isobe K
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Journal Title
Brain Dev
Volume: 35(1)
Pages: 17-25
Peer Reviewed
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[Journal Article] The effect of blood transfusion on cerebral hemodynamics in preterm infants2012
Author(s)
Koyano K, Kusaka T, Nakamura S, Nakamura M, Konishi Y, Miki T, Ueno M, Yasuda S, Okada H, Nishida T, Isobe K, Itoh S
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Journal Title
Transfusion
Volume: (in press)
Peer Reviewed
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[Journal Article] Functional lateralization of sensorimotor cortex in infants measured using multichannel near-infrared spectroscopy2011
Author(s)
Kusaka T, Isobe K, Miki T, Ueno M, Koyano K, Nakamura S, Nakamura M, Konishi Y, Kuboi T, Kato I, Okubo K, Yasuda S, Nishida T, Itoh S.
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Journal Title
Pediatr Res.
Volume: 69(5 Pt 1)
Pages: 430-5
Peer Reviewed
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