2012 Fiscal Year Final Research Report
Investigation of the mechanism of ductus arteriosus closure affected by changes in serum osmolality
| Project/Area Number |
22591205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
AOKI Rika 横浜市立大学, 医学研究科, 客員研究員 (50542437)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Utako 横浜市立大学, 医学部, 講師 (70404994)
MINAMISAWA Susumu 横浜市立大学, 医学研究科, 客員教授 (40257332)
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| Research Collaborator |
SEKI Kazuo 横浜市立大学, 市民総合医療センター, 准教授 (50236072)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 未熟児医学 / 動脈管 / 血清浸透圧 / TRPM3 |
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| Research Abstract |
We assessed the hypothesis that serum hypoosmolality promoted closure of the ductus arteriosus (DA). We showed both from human clinical observations and rat experiments that serum hypoosmolality augmented DA closure. The results suggest the importance of maintaining the serum osmolality in a proper levelfor early preterm infants early after birth.
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Research Products
(7 results)
