2012 Fiscal Year Final Research Report
Predictors of metabolic syndrome in preterm and low birth weight infants
| Project/Area Number |
22591208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKANO Yuya 昭和大学, 医学部, 助教 (40465224)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 早産児 / アディポネクチン / レプチン / 生活習慣病 / 内臓脂肪 |
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| Research Abstract |
The longitudinal changes in adiponectin multimer levels differ in preterm and term infants. The ratio of high-molecular-weight adiponectin to total adiponectin in preterm infants at term- and 6 months-equivalent age was significantly lower than that in term infants at corresponding time points. Postnatal growth including fat tissue accumulation may contribute to adiponectin increases from birth to term-equivalent age, but it was not associated with the ratio of high-molecular-weight adiponectin changes in preterm infants. Further studies are needed to identify the factors that alter adiponectin multimer levels in preterm infants and determine whether they maybe associated with a higher risk of insulin resistance in the future.
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