2012 Fiscal Year Final Research Report
Umbilical cord blood-derived cell therapy for perinatal brain damage
| Project/Area Number |
22591213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
NAKANISHI Keiko 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 (50280813)
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| Research Collaborator |
HIGASHI Yujiro 愛知県心身障害者コロニー発達障害研究所, 周産期学部, 部長
OHIRA Atsuhiko 名古屋大学, 小児科, 研究員
SATO Yoshiaki 名古屋大学, 総合周産期母子医療センター・新生児科, 病院助教
ITO Miharu 名古屋大学, 総合周産期母子医療センター・新生児科, 医師
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| Project Period (FY) |
2010 – 2012
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| Keywords | 新生児低酸素性虚血性脳症 / 臍帯血幹細胞 |
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| Research Abstract |
We investigated the therapeutic effect of umbilical cord blood-derived cells (UCBC) on neonatal hypoxia-ischemia encephalopathy (HIE) model in rats. Mononuclear cells isolated from rat umbilical cord blood were propagated in culture using growth factors and the cells were administered to HIE model of rats. Administration of UCBC decreased the infarct size and improved motor functions. These results indicate that administration of UCBC is a promising therapy for neonatal hypoxia-ischemia.
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[Journal Article] A wide spectrum of clinical and brain MRI findings in patients with SLC19A3 mutations.2010
Author(s)
Yamada K, Miura K, Hara K, Suzuki M, Nakanishi K, Kumagai T, Ishihara N, Yamada Y, Kuwano R, Tsuji S, and Wakamatsu N.
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Journal Title
BMC Medical Genetics
Volume: 11
Pages: 171-178
DOI
Peer Reviewed
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