2012 Fiscal Year Final Research Report
Analysis for the mechanism of prurigo reaction focusing on basophils
| Project/Area Number |
22591218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOKOZEKI Hiroo 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90210608)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Takahiro 東京医科歯科大学, 医学部, 非常勤講師 (30235361)
KAORU Takayama 東京医科歯科大学, 医学部附属病院, 講師 (10420283)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Keigo 独立行政法人理化学研究所, 研究員 (80360618)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 好塩基球 / 痒疹 / Th2 サイトカイン / プロテアーゼ / モノクローナル抗体 / STAT6 / IgE / 蕁麻疹 |
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| Research Abstract |
Prurigo is a common disease characterized by urtical papules and bodules with severe itching. The pathological mechanism causing prurigo remains unclear, although Th2-type immunity has been implicated in its etiology and our recent study showed a number of basophils in prurigo lesion. The present study demonstrated that repeated intra-dermal injection of TNP-OVA to dosal skin lesions. Histologicallly, marked hyperkeratosis with irregular acanthosis was accompanied by dense infiltrate comprising mononuclear cells, eoshinophils, and increased number of mast cells.
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[Journal Article] 日本皮膚科学会ガイドライン慢性痒疹診療ガイドライン
Author(s)
佐藤貴浩(東京医科歯科大学医学部皮膚科), 横関博雄, 片山一朗, 室田浩之, 新樹, 朴紀央, 椛島健治,中溝聡, 高森建二, 塩原哲夫, 三橋善比古, 森田栄伸
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Journal Title
日本皮膚科学会雑誌
Volume: 122巻1号
Pages: 1-162012
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