2012 Fiscal Year Final Research Report
Basic studies on therapeutic utilities ofIL-27 for malignant melanoma, psoriasis and alopecia areata.
| Project/Area Number |
22591220
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
NAGAI Hiroshi 神戸大学, 医学部附属病院, 講師 (80335447)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Takayuki 東京医科大学, 医学部, 教授 (80202406)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 悪性黒色腫 / 乾癬 / サイトカイン |
|---|
| Research Abstract |
We conducted studies on therapeutic effects of interleukin (IL)-27 on malignant melanoma and psoriasis in murine models. We also examined the effects ofIL-27 on chemokine production from human epidermal keratinocytes and demonstrated that IL-27 and IL-17 exerted opposite effects on tumor necrosis factor-alpha-mediated psoriasis relatedchemokine production.
|
Research Products
(7 results)
