Networks of single nucleotide polymorphisms of candidate genes to increase psoriasis risk.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591223
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Yamaguchi University
• Principal Investigator: MUTO Masahiko 山口大学, 大学院・医学系研究科, 教授 (40175625)
• Co-Investigator(Kenkyū-buntansha): ICHIMIYA Makoto 山口大学, 大学院・医学系研究科, 准教授 (20314809)
• Project Period (FY): 2010 – 2012
• Keywords: 乾癬 / 発症原因遺伝子 / 高次構造

Research Abstract

The present study was to investigate the pathophysiological aspects concerning the development of psoriasis (psoriasis vulgaris (N=200), generalized pustular psoriasis(N=10), psoriatic arthritis(N=30) in Japan. We can summarize the results of the present study as follows: first, immunological markers (IL-12B, IL-36RN, TNF-α, and CTLA4) as well as HLA might be involved in the development of psoriasis. Second, genetic defects of the IL-36RN are essential to develop the generalized pustular psoriasis but not psoriasis vulgaris. Moreover these genetic defects of IL-36RN are due to the founder effect of the gene. Third, FABP5 combining linoleic acid is found to be very important in regulating cytokeratin gene K1 of the epidermis , by experiments using FABP5 knockout mice.

Research Products

• [Journal Article] Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene (2012)
  • Author(s): Sugawara T., Nemoto K., Adachi Y., Yamano N., Tokuda N., Muto M., Okuyama R., Sakai S., Owada Y.
  • Journal Title: Exp. Dermatol. Volume: 21 Pages: 543-546
  • DOI: DOI:10.1111/j.1600.0625.2012.01514.x
  • Peer Reviewed
• [Journal Article] 新しい治療への期待-顆粒球吸着療法- (2012)
  • Author(s): 根本圭、武藤正彦
  • Journal Title: 日皮会誌 Volume: 122 Pages: 3219-3221
• [Journal Article] ステロイド外用薬でコントロールできた疱疹状膿痂疹 (2012)
  • Author(s): 根本圭、若松研弥、一宮誠、武藤正彦
  • Journal Title: 皮膚病診療 Volume: 34 Pages: 647-650
• [Journal Article] Characterization of tight junctions and their disruption by UVB in human epidermis and cultured keratinocytes (2011)
  • Author(s): Yuki T., Hachiya A., Kusaka A., Sriwiriyanont P., Visscher MO., Morita K., Muto M., Miyachi Y., Sugiyama Y., Inoue S.
  • Journal Title: J. Invest. Dermatol. Volume: 131 Pages: 744-752
  • DOI: DOI:10.1038/jid.2010.385
  • Peer Reviewed
• [Journal Article] Genotyping of human killer cell immunoglobulin-like receptor genes in Japanese patients with psoriatic arthritis, generalized pustular psoriasis or psoriasis vulgaris (2011)
  • Author(s): Nemoto K., Muto M.
  • Journal Title: Bull. Yamaguchi Med. School Volume: 58 Pages: 37-43
  • URL: http://ds.cc.yamaguchi-u.ac.jp/bulletin/left.html
  • Peer Reviewed
• [Journal Article] Association between T-lymphocyte regulatory gene CTLA4 single nucleotide polymorphism at position 49 in exon 1 and HLA-DRB1*08 in Japanese patients with psoriasis vulgaris (2011)
  • Author(s): Muto M., Deguchi H., Tanaka A., Inoue T., Ichimiya M.
  • Journal Title: J. Dermatol. Sci. Volume: 62 Pages: 70-71
  • DOI: DOI:10.1016/j.jdermsci.2010.10.012
  • Peer Reviewed
• [Journal Article] Epidermal FABP(FABP5) regulates keratinocyte differentiation by 13(s)-HODE-mediated activation of the NF-κB signaling pathway (2011)
  • Author(s): Ogawa E., Owada Y., Ikawa S., Adachi Y., Egawa T., Nemoto K., Suzuki K., Hishinuma T., Kawashima H., Kondo H., Muto M., Aiba S., Okuyama R.
  • Journal Title: J. Invest. Dermatol. Volume: 131 Pages: 604-612
  • DOI: DOI:10.1038/jid.2010.342
  • Peer Reviewed
• [Journal Article] Prevalence of dermatological disorders in Japan: A nationwide, cross-sectional (2010)
  • Author(s): Furue M., Yamazaki S., Jimbow K., Tsuchida T., Amagai M., Tanaka T., Matsunaga K., Muto M., Morita E., Akiyama M., Soma Y., Terui T., Manabe M.
  • Journal Title: seasonal, multicenter, hospital-based study, J. Dermatol. Volume: 38 Pages: 310-320
  • DOI: DOI:10.1111/j.1346-8138.2011.01209.x
  • Peer Reviewed
• [Journal Article] Analysis of single nucleotide polymorphisms of methylene- tetrahydrofolate reductase in Japanese psoriasis patients, Bull (2010)
  • Author(s): Deguchi H., Tanaka A., Muto M.
  • Journal Title: Bull. Yamaguchi Med. School Volume: 57 Pages: 41-48
  • URL: http://ds.cc.yamaguchi-u.ac.jp/bulletin/left.html
  • Peer Reviewed
• [Journal Article] The detection of genetic variants concerning psoriasis susceptibility (2010)
  • Author(s): Muto M.
  • Journal Title: Dermatologie in Beruf und Umwelt Volume: 58(2) Pages: 82-83
• [Journal Article] Silencing HSF1 by short hairpin RNA decreases cell proliferation and enhances sensitivity to hyperthermia in a human melanoma cell line (2010)
  • Author(s): Nakamura Y., Fujimoto M., Hayashida N., Takii R., Nakai A., Muto M.
  • Journal Title: J. Dermatol. Sci. Volume: 60 Pages: 187-192
  • DOI: DOI:10.1016/j.jdermsci.2010.09.009
  • Peer Reviewed
• [Journal Article] A case of psoriasis verrucosa (2010)
  • Author(s): Wakamatsu K., Naniwa K., Hagiya Y., Ichimiya M., Muto M.
  • Journal Title: J. Dermatol. Volume: 37 Pages: 1060-1062
  • DOI: DOI:10.1111/j.1346-8138.2010.00944.x
  • Peer Reviewed
• [Journal Article] The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist
  • Author(s): Sugiura K., Takemoto A., Yamaguchi M.
  • Journal Title: J. Invest, Dermatol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Endoscopic groin lymph node dissection as a preferable technique for malignant skin neoplasms
  • Author(s): Ichimiya M., Goishi K., Muto M.
  • Journal Title: J. Plast. Surg. Hand Surg. Volume: (in press)
  • Peer Reviewed
• [Presentation] Genetic Polymorphisms of IL36RN, KIR and HLA in Japanese Patients with Generalized Pustular Psoriasis (2012)
  • Author(s): Masahiko Muto, Michiya Yamaguchi, Akemi Takemoto, Kenichiro Naniwa, Makoto Ichimiya
  • Organizer: 2ndEastern Asia Dermatology Congress
  • Place of Presentation: Beijing, China
  • Year and Date: 20120613-15
• [Presentation] Genetic association study shows significance of a combination of CTLA4 gene and HLA-DRB1*08 concerning psoriasis-risk genes (2011)
  • Author(s): Muto M, Tanaka A, Wakamatsu K, Yamaguchi M, Takemoto A
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20110524-29
• [Presentation] Allelic polymorphism and haplotypes of killer cell immunoglobulin-like receptor genes in huma melanoma (2010)
  • Author(s): Muto M, Yamaguchi M, Deguchi H, Abe Y, Ichimiya M
  • Organizer: The 1st Eastern Asia Dermatology Congress
  • Place of Presentation: Fukuoka, Hotel New Otani Hakata
  • Year and Date: 20100930-1002
• [Presentation] The detection of genetic variants concerning psoriasis susceptibility (2010)
  • Author(s): Muto M
  • Organizer: The 9thmeeting of the German-Japanese Society of Dermatology
  • Place of Presentation: Weimar, Germany
  • Year and Date: 20100608-10
• [Book] 乾癬『今日の治療指針』 (2013)
  • Author(s): 武藤正彦、他
  • Total Pages: 1045-1046
  • Publisher: 医学書院
• [Remarks]
  • URL: https://www.bsbank.jp