2012 Fiscal Year Final Research Report
Identification and characterization of cancer stem cells in skin squamous cell carcinoma.
| Project/Area Number |
22591225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MURAO Kazutoshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (40363171)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 皮膚腫瘍学 / 癌幹細胞 |
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| Research Abstract |
To investigate cancer stem cell in human SCC, I first examined the expression of CD133 and smad4 which were considered to be marked on stem cells. Less than 5% of cells were positive for these protein. Next, we tried to perform SP cell isolated from human SCC into nude mouse to evaluate if they had capacity to generate another tumor. However, human SCC cells were rarely grown on immune compromised mise.
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