2012 Fiscal Year Final Research Report
evelopment ofprognostic models for predicting the outcome of cutaneous T-cell lymphomas based on biological prognostic factors
| Project/Area Number |
22591227
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KAWAI Kazuhiro 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (90242411)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ATL / 皮膚型 ATL / 予後因子 / 臨床的予後因子 / 生物学的予後因子 / 多変量解析 / 予後予測モデル |
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| Research Abstract |
To develop a prognostic model for predicting the outcome of primary 'cutaneous-type' ATL, prognostic factors in the smoldering-type ATL patients with cutaneous lesions were analyzed. Independent prognostic factors for poor overall survival in multivariate analyses were higher age, high serum LDH, and higher soluble IL-2 receptor levels, while erythroderma and CXCR3 expression on tumor cells were associated with good survival. High serum LDH and higher soluble IL-2 receptor levels were also associated with higher risk for acute crisis or death from ATL. Patients with erythroderma or CXCR3-/T-bet-expressing tumor cells had lower risk for disease progression.
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