2012 Fiscal Year Final Research Report
The establishment of gadolinium-induced skin fibrosis and calcification mice model.
| Project/Area Number |
22591237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Gunma University |
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Principal Investigator |
ISHIKAWA Osamu 群馬大学, 大学院・ 医学系研究科, 教授 (90168188)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腎性全身性線維症 / ガドリニウム / 線維化 / 石灰化 / 間葉系幹細胞 |
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| Research Abstract |
Nephrogenic systemic fibrosis (NSF) is an acquired disorder characterized by systemic fibrosis and abnormal calcification in patients with severe renal dysfunction. Growing evidence supports the hypothesis that gadolinium (Gd)-containing contrast agents used for magnetic resonance imaging trigger the development of NSF. The aim of this study was to establish the Gd-induced skin fibrosis and calcification mice model. Subcutaneous injection of bone marrow-derived mesenchymal stem cells and Gd-loaded hydorogel induced skin fibrosis in mice, but not skin calcification. Next we will examine the mechanism of Gd-induced skin fibrosis.
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