2012 Fiscal Year Final Research Report

The establishment of gadolinium-induced skin fibrosis and calcification mice model.

Research Project

Project/Area Number	22591237
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Dermatology
Research Institution	Gunma University
Principal Investigator	ISHIKAWA Osamu 群馬大学, 大学院・医学系研究科, 教授 (90168188)
Project Period (FY)	2010 – 2012
Keywords	腎性全身性線維症 / ガドリニウム / 線維化 / 石灰化 / 間葉系幹細胞
Research Abstract	Nephrogenic systemic fibrosis (NSF) is an acquired disorder characterized by systemic fibrosis and abnormal calcification in patients with severe renal dysfunction. Growing evidence supports the hypothesis that gadolinium (Gd)-containing contrast agents used for magnetic resonance imaging trigger the development of NSF. The aim of this study was to establish the Gd-induced skin fibrosis and calcification mice model. Subcutaneous injection of bone marrow-derived mesenchymal stem cells and Gd-loaded hydorogel induced skin fibrosis in mice, but not skin calcification. Next we will examine the mechanism of Gd-induced skin fibrosis.

(1 results)