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2013 Fiscal Year Final Research Report

Creation of atopic dermatitis model mouse using double knock out mouse

Research Project

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Project/Area Number 22591240
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKagawa University

Principal Investigator

YONEDA Kozo  香川大学, 医学部附属病院, 准教授 (60260626)

Co-Investigator(Kenkyū-buntansha) KUBOTA Yasuo  香川大学, 医学部, 教授 (10126047)
ARAKI Nobukazu  香川大学, 医学部, 教授 (10202748)
NAKAI Kozo  香川大学, 医学部, 助教 (40363204)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywordsロリクリン / ノックアウトマウス / 魚鱗癬 / アトピー性皮膚炎
Research Abstract

Atopic dermatitis is one of intractable skin diseases. The clinical feature of this disease is itchy eczema. This disease is caused by mutations in filaggrin gene now. Loricrin is major constituent of marginal band of epidermal corneocyte. The clinical aspects of the variant form of Vohwinkel syndrome are mutilating keratoderma with ichthyosis. This phenotype is similar to ichthyosis vulgaris. Ichthyosis vulgaris is caused by homozygous or compound heterozygous mutations in the filaggrin gene. The aim of this project is creation of atopic dermatitis mouse model using loricrin knock out mouse.

  • Research Products

    (48 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (40 results) Presentation (8 results)

  • [Journal Article] Detection of apoptotic keratinocytes in a case of bullous pemphigoid developed after graft-versus-host disease2014

    • Author(s)
      Yoneda K, Demitsu T, Kakurai M, Narita T, Nakai K, Kubota Y, Ishii N and Hashimoto T
    • Journal Title

      Acta Derm Venereol

      Volume: 94 Pages: 231-232

  • [Journal Article] Multi-branched acquired periungual fibrokeratoma2014

    • Author(s)
      Moriue T, Yoneda K, Moriue J, Nakai K and Kubota Y
    • Journal Title

      JAMA Dermatol

      Volume: (Epub ahead of print)

    • DOI

      10.1001/jamadermatol.2013.6631

  • [Journal Article] Two cases of nevus sebaceous accompanying secondary tumors with Klothov expression2014

    • Author(s)
      Nakai K, Yoneda K, Haba R, Kushida Y, Katsuki N, Moriue J, Moriue T, Ishikawa E, Inoue S and Kubota Y
    • Journal Title

      J Dermatol

      Volume: 41 Pages: 171-172

    • DOI

      10.1111/1346-8138.12371

  • [Journal Article] A survey of the factors associated with concerns about oral antihistamine use in Japanese pruritic 30. Hosokawa Y, Yoneda K, Nakai K, Moriue J and Kubota Y: Completely thrombosed venous aneurysm in great saphenous vein2013

    • Author(s)
      Moriue J, Yoneda K, Nakai K, Hosokawa Y, Moriue T, and Kubota Y
    • Journal Title

      Ann Dermatol

      Volume: 25 Pages: 268-270

  • [Journal Article] Paraneoplastic pemphigus mimicking toxic epidermal necrolysis associated with B-cell lymphoma2013

    • Author(s)
      Yamada T, Nakamura S, Demitsu T, Nakamura T, Iida E, Yoneda K, Fukuda S and Hashimoto T
    • Journal Title

      J Dermatol

      Volume: 40 Pages: 286-288

  • [Journal Article] Dexamethasone induces caveolin-1 in vascular endothelial cells: implications for attenuated responses to VEGF2013

    • Author(s)
      Igarashi J, Hashimoto T, Shoji K, Yoneda K, Tsukamoto I, Moriue T, Kubota Y and Kosaka H
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 304 Pages: C790-800

  • [Journal Article] Sphingosine 1-phosphate attenuates peroxide-induced apoptosis in HaCaT cells cultured in vitro2013

    • Author(s)
      Moriue T, Igarashi J, Yoneda K, Hashimoto T, Nakai K, Kosaka H and Kubota Y
    • Journal Title

      Clin Exp Dermatol

      Volume: 38 Pages: 638-645

  • [Journal Article] Primary dermal melanoma latent for more than 10 years2013

    • Author(s)
      Moriue J, Yoneda K, Moriue T, Nakai K, Katsuki N, Haba R, Ikeda M and Kubota Y
    • Journal Title

      Ann Dermatol

      Volume: 25 Pages: 385-386

  • [Journal Article] Successful treatment of primary cutenous anaplastic large cell lymphoma with intralesional methotrexate therapy2013

    • Author(s)
      Yokoi I, Ishikawa E, Koura A, Hosokawa Y, Tamai A, Nakai K, Moriue J, Moriue T, Yoneda K and Kubota Y
    • Journal Title

      Acta Derm Venereol

      Volume: (Epub ahead of print)

    • DOI

      10.2340/00015555-1692

  • [Journal Article] Deranged epidermal differentiation in kl/kl mouse and the effects of Klotho siRNA on the differentiation of HaCaT cells2013

    • Author(s)
      Nakai K, Yoneda K, Haba R, Kushida Y, Katsuki N, Moriue T, Kosaka H, Kubota Y and Inoue S
    • Journal Title

      Exp Dermatol

      Volume: (Epub ahead of print)

    • DOI

      10.1111/exd.12258

  • [Journal Article] Combination effects of cosmetic moisturisers in the topical treatment of acne vulgaris2012

    • Author(s)
      Munehiro A, Murakami Y, Shirahige Y, Nakai K, Moriue T, Matsunaka H, Yoneda K and Kubota Y
    • Journal Title

      J Dermatol Treat

      Volume: 23 Pages: 172-176

  • [Journal Article] A case of Degos disease successfully treated with corticosteroid combined with cyclophosphamide2012

    • Author(s)
      Kameda T, Dobashi H, Yoneda K, Susaki K, Kuno T, Murao K and Ishida T
    • Journal Title

      Rheumatol Int

      Volume: 32 Pages: 2169-2173

  • [Journal Article] Scedosporium apiospermum skin infection mimicking tuberous xanthoma2012

    • Author(s)
      Yoneda K, Nakai K, Moriue T, Ishikawa E, Demitsu T, Ohkusu K and Kubota Y
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 316-318

  • [Journal Article] Numerous mucin nodules in a patient with seropositive wide spread discoid lupus erythematosus2012

    • Author(s)
      Yoneda K, Moriue J, Nakai K, Demitsu T, Moriue T, Yokoi I, Munehiro A, Dobashi H and Kubota Y
    • Journal Title

      Ann Dermatol

      Volume: 24 Pages: 112-114

  • [Journal Article] The profilaggrin N-terminal domain is absent in pityriasis rotunda2012

    • Author(s)
      Yoneda K, Presland RB, Demitsu T, Shimizu T and Kubota Y
    • Journal Title

      Br J Dermatol

      Volume: 166 Pages: 227-229

  • [Journal Article] Juvenile xanthogranuloma with lichenoid appearance2012

    • Author(s)
      Yoneda K, Demitsu T and Kubota Y
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 462-465

  • [Journal Article] Interaction of the profilaggrin N-terminal domain with loricrin in human cultured keratinocytes and epidermis2012

    • Author(s)
      Yoneda K, Nakagawa T, Lawrence OT, Huard J, Demitsu T, Kubota Y and Presland RB
    • Journal Title

      J Invest Dermatol

      Volume: 132 Pages: 1206-1214

  • [Journal Article] Effect of sequential application of topical adapalene and clindamycin phosphate in the treatment of Japanese patients with acne vulgaris2012

    • Author(s)
      Kubota Y, Munehiro A, Shirahige Y, Nakai K, Katsuura J, Moriue T, Murakami Y, Matsunaka H and Yoneda K
    • Journal Title

      J Dermatol Treat

      Volume: 23 Pages: 37-45

  • [Journal Article] Inflammatory disseminated superficial porokeratosis with an unusual clinical feature of the pruritic, erythematous papules preceding annular brownish pigmentation2012

    • Author(s)
      Wakatabi K, Kakurai M, Yamada T, Umemoto N, Demitsu T and Yoneda K
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 946-948

  • [Journal Article] Cutaneous Mycobacterium marinum infection mimicking felon in a patient with psoriatic arthritis treated with infliximab2012

    • Author(s)
      Demitsu T, Yamada T, Umemoto N, Narita T, Kakurai M and Yoneda K
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 970-971

  • [Journal Article] Primary cutaneous cryptococcosis in a patient with CREST syndrome2012

    • Author(s)
      Ishikawa E, Yoneda K, Nakai K, Moriue J, Yokoi I, Munehiro A and Kubota Y
    • Journal Title

      Eur J Dermatol

      Volume: 22 Pages: 421-422

  • [Journal Article] Macular lymphocytic arteritis in a patient with rheumatoid arthritis2012

    • Author(s)
      Munehiro A, Yoneda K, Koura A, Nakai K and Kubota Y
    • Journal Title

      Eur J Dermatol

      Volume: 22 Pages: 427-42

  • [Journal Article] Pinch and ligation method: a new non-surgical approach to viral warts2012

    • Author(s)
      Moriue T, Yoneda K, Moriue J, Nakai K, Yokoi I, Fujita N, Munehiro A, Maeda R and Kubota Y
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 1108-1109

  • [Journal Article] Pustular psoriasis precipitated by cytomegalovirus infection2012

    • Author(s)
      Yoneda K, Matsuoka-Shirahige Y, Demitsu T and Kubota Y
    • Journal Title

      Br J Dermatol

      Volume: 167 Pages: 1186-1189

  • [Journal Article] Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies2012

    • Author(s)
      Nakai K, Yoneda K, Hosokawa Y, Moriue T, Presland RB, Fallon PG, Kabashima K, Kosaka H and Kubota Y
    • Journal Title

      Am J Pathol

      Volume: 181 Pages: 969-977

  • [Journal Article] A founder effect of c.1938delC in ITGB4 underlies junctional epidermolysis bullosa and its application for prenatal testing2011

    • Author(s)
      Natsuga K, Nishie W, Shinkuma S, Nakamura H, Arita K, Yoneda K, Kusaka T, Yanagihara T, Kosaki R, Sago H, Akiyama M and Shimizu H
    • Journal Title

      Exp Dermatol

      Volume: 20 Pages: 74-76

  • [Journal Article] Lipid peroxidation-induced VEGF expression in the skin of KKAy obese mice2011

    • Author(s)
      Nakai K, Yoneda K, Ishihara Y, Ohmori K, Moriue T, Igarashi J, Kohno M, Kosaka H and Kubota Y
    • Journal Title

      Exp Dermatol

      Volume: 20 Pages: 388-393

  • [Journal Article] Skin infiltration of pelvic actinomycosis after total gastrectomy2011

    • Author(s)
      Yoneda K, Nakai K, Hosokawa Y, Moriue T, Demitsu T and Kubota Y
    • Journal Title

      Eur J Dermatol

      Volume: 21 Pages: 290-291

  • [Journal Article] Unilateral palm pompholyx in a patient with amyotrophic lateral sclerosis2011

    • Author(s)
      Nakai K, Yoneda K, Moriue T, Hosokawa Y, Yokoi I and Kubota Y
    • Journal Title

      Eur J Dermatol

      Volume: 21 Pages: 445-446

  • [Journal Article] Sarcoidosis presenting transepidermal elimination2011

    • Author(s)
      Yoneda K, Kakurai M, Umemoto N, Nakai K, Kubota Y and Demitsu T
    • Journal Title

      Eur J Dermatol

      Volume: 21 Pages: 616-617

  • [Journal Article] Consequences of two different amino-acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis2011

    • Author(s)
      Natsuga K, Nishie W, Smith BJ, Shinkuma S, Smith TA, Parry DA, Oiso N, Kawada A, Yoneda K, Akiyama M and Shimizu H
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 1869-1876

  • [Journal Article] Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma2010

    • Author(s)
      Yoneda K, Demitsu T, Nakai K, Moriue T, Ogawa W, Igarashi J, Kosaka H and Kubota Y
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 16184-16194

  • [Journal Article] Community-based epidemiological study of psychosocial effects of acne in Japanese adolescents2010

    • Author(s)
      Kubota Y, Shirahige Y, Nakai K, Katsuura J, Moriue T and Yoneda K
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 617-622

  • [Journal Article] Clinical efficacy of reserpine as "add-on therapy" to antihistamines in patients with recalcitrant chronic idiopathic urticaria and urticarial vasculitis2010

    • Author(s)
      Demitsu T, Yoneda K, Kakurai M, Sasaki K, Hiratsuka Y, Azuma R, Yamada T and Umemoto N
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 827-829

  • [Journal Article] Bevacizumab-induced hand-foot syndrome: circumscribed type2010

    • Author(s)
      Munehiro A, Yoneda K, Nakai K, Demitsu T, Moriue T, Moriue J, Yokoi I, Fujita N, Matsuura N, Ishikawa S, Yokomise H and Kubota Y
    • Journal Title

      Br J Dermatol

      Volume: 162 Pages: 1411-1413

  • [Journal Article] Expression of wild-type, but not mutant, loricrin causes programmed cell death in HaCaT keratinocytes2010

    • Author(s)
      Yoneda K, Demitsu T, Manabe M, Igarashi J, Kosaka H, Inagaki N, Takahashi H, Kon A, Kakurai M and Kubota Y
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 956-964

  • [Journal Article] Late radiation dermatitis of the right arm after cardiac catheterization2010

    • Author(s)
      Yoneda K, Nakai K, Demitsu T, Moriue T, Moriue J, Yokoi I, Munehiro A, Noma T, Kohno M and Kubota Y
    • Journal Title

      Eur J Dermatol

      Volume: 20 Pages: 654-656

  • [Journal Article] Seborrhoeic keratoses and acanthosis nigricans in a long-term survivor of thanatophoric dysplasia2010

    • Author(s)
      Nakai K, Yoneda K, Moriue T, Munehiro A, Fujita N, Moriue J, Yokoi I, Haba R, Itoh S and Kubota Y
    • Journal Title

      Br J Dermatol

      Volume: 163 Pages: 656-658

  • [Journal Article] Zosteriform cutaneous metastasis of lung adenocarcinoma

    • Author(s)
      Kubota Y, Nakai K, Munehiro A, Moriue J and Yoneda K
    • Journal Title

      J Clin Exp Dermatol Res

      Volume: 36 (in press)

  • [Journal Article] Pachyonychia congenita in Japan: report of familial cases with a recurrent KRT16 mutation and review of the literature

    • Author(s)
      Inaba Y, Kanazawa N, Furukawa F, Sakurane Y, Nakano H, Sawamura D, Yoneda K, Hamada T and Hashimoto T
    • Journal Title

      Eur J Dermatol

      Volume: (in press)

  • [Presentation] Cytomegalovirus infection is one of the precipitating factors for pustular psoriasis2012

    • Author(s)
      Yoneda K, Matsuoka-Shirahige Y, Demitsu T and Kubota Y
    • Organizer
      The 37^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Okinawa
    • Year and Date
      2012-12-07
  • [Presentation] Klotho regulates the differentiation and tumorgenesis of epidermal keratinocytes2012

    • Author(s)
      Nakai K, Inoue S, Haba R, Kushida Y, Katsuki N, Hosokawa Y, Moriue T, Yoneda K and Kubota Y
    • Organizer
      The 37^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Okinawa
    • Year and Date
      2012-12-07
  • [Presentation] Reduced expression of EGF receptor, E-cadherin and occludin is due to loricrin deficiency in the skin of flaky tail mice2011

    • Author(s)
      Nakai K, Yoneda K, Hosokawa Y, Moriue T and Kubota Y
    • Organizer
      The 36^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-12-09
  • [Presentation] Direct effects of bevacizumab on cell proliferation and cell signaling pathways in HaCaT cells2011

    • Author(s)
      Hosokawa Y, Yoneda K, Moriue T, Nakai K and Kubota Y
    • Organizer
      The 36^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-12-09
  • [Presentation] The profilaggrin N-terminal domain is absent in pityriasis rotunda2011

    • Author(s)
      Yoneda K, Presland RB, Demitsu T, Shimizu T and Kubota Y
    • Organizer
      The 36^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-12-09
  • [Presentation] Abnormally aggregated caveolin-1 in the cytoplasm of cellular model of classic Vohwinkel syndrome2010

    • Author(s)
      Yoneda K, Nakai K, Moriue T, Demitsu T and Kubota Y
    • Organizer
      The 35^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Wakayama
    • Year and Date
      2010-12-04
  • [Presentation] The effects of oxidized LDL on VEGF production in HaCaT cells: a possible mechanism for psoriasis in metablic syndrome2010

    • Author(s)
      Nakai K, Yoneda K, Ishihara Y, Ohmori K, Moriue T, Igarashi J, Kohno M, Kosaka H and Kubota Y
    • Organizer
      The 35^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Wakayama
    • Year and Date
      2010-12-03
  • [Presentation] Pitavastatin suppresses lipid peroxidation-induced VEGF expression in the skin of KKAy metabolic syndrome mice2010

    • Author(s)
      Nakai K, Yoneda K, Ishihara Y, Ohmori K, Moriue T, Igarashi J, Kohno M, Kosaka H and Kubota Y
    • Organizer
      17^<th> Annual Meeting of The Society for Free Radical Biology and Medicine
    • Place of Presentation
      Orlando
    • Year and Date
      2010-11-18

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Published: 2015-07-16  

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