2012 Fiscal Year Final Research Report
Development of living skin equivalent models over-expressing IL-22R on epidermal keratinocytes
| Project/Area Number |
22591241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Ehime University |
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Principal Investigator |
TOHYAMA Mikiko 愛媛大学, 医学部附属病院, 助教 (60263935)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乾癬 / IL-22 / IL-22レセプター |
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| Research Abstract |
IL-22 is an essential cytokine in the pathogenesis of psoriasis. We have found that IL-22 receptor expression is increased in the epidermal keratinocytes of psoriasis. In this study, we elucidated that IFN-αenhances IL-22R expression in cultured keratinocytes, and that IL-22-inducible gene expression is enhanced by nuclear Bcl-3 which is increased by IL-22, particular when IL-22R is over-expressed. These findings suggest that living skin equivalent models highly-expressing IL-22R on epidermal keratinocytes may be a useful too for studying the pathogenesis of psoriasis.
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