2012 Fiscal Year Final Research Report
Investigation of IL-23/Th17 axis in pathogenesis of psoriasis using a mouse model.
| Project/Area Number |
22591242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kochi University |
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Principal Investigator |
TAKAISHI Mikiro 高知大学, 教育研究部医療学系, 助教 (10303223)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Ken 高知大学, 教育研究部医療学系, 助教 (20274392)
NAKAJIMA Kimiko 高知大学, 教育研究部医療学系, 講師 (20403892)
SANO Shigetoshi 高知大学, 教育研究部医療学系, 教授 (80273621)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乾癬 |
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| Research Abstract |
The roles of IL-23 and IL-22 in pathogenesis of psoriasis were investigated using K5.Stat3C transgenic mice, as a unique mouse model for psoriasis. The development of psoriasis-like lesions was attenuated in the K5.Stat3C mice being deficient in IL-23 production. In other hands, the lesions in the IL-22 deficient mice were generated as same as in the control mice. The results indicated that IL-23 played a significant role in psoriasis and that some alternative pathways could compensate the loss of IL-22 in development of psoriasis-like lesions.
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[Journal Article] Barrier abnormality due to ceramide deficiency leads to psoriasiform inflammation in a mouse model.2013
Author(s)
Nakajima K, Terao M, Takaishi M, Kataoka S, Goto-Inoue N, Setou M, Horie K, Sakamoto F, Ito M, Azukizawa H, Kitaba S, Murota H, Itami S, Katayama I, Takeda J, Sano S.
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Journal Title
DOI
Peer Reviewed
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[Journal Article] GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.2012
Author(s)
Tarutani M, Nakajima K, Uchida Y, Takaishi M, Goto-Inoue N, Ikawa M, Setou M, Kinoshita T, Elias PM, Sano S, Maeda Y
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Journal Title
J Invest Dermatol.
Volume: 132(8)
Pages: 2019-25
DOI
Peer Reviewed
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[Journal Article] FDG PET/CT is a powerful tool for detecting subclinical arthritis in patients with psoriatic arthritis and/or psoriasis vulgaris.2011
Author(s)
Takata T, Taniguchi Y, Ohnishi T, Kohsaki S, Nogami M, Nakajima H, Kumon Y, Terada Y, Ogawa Y, Tarutani M, Sano S.
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Journal Title
J Dermatol Sci.
Volume: 64(2)
Pages: 144-7
DOI
Peer Reviewed
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[Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model.2011
Author(s)
Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S.
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Journal Title
J Immunol.
Volume: 186(7)
Pages: 4481-9
DOI
Peer Reviewed
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[Journal Article] Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor.2011
Author(s)
Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, DiGiovanni J, Sano S.
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Journal Title
J Invest Dermatol.
Volume: 131(1)
Pages: 108-17
DOI
Peer Reviewed
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[Presentation] STA-21, a stat3 inhibitor, induces differentiation of normal human epidermal keratinocytes and human, keratinocyte derived cell lines.2010
Author(s)
Takaishi M, Yokogawa M, Miyoshi K, Nakajima K, DiGiovanni J, Sano S.
Organizer
70th SID 2010 Annual Meeting
Place of Presentation
Hilton Atlanta Hotel, Atlanta, U.S.A
Year and Date
2010-05-05
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