2012 Fiscal Year Final Research Report
Generation and analysis of model mouse for psoriatic arthritis
| Project/Area Number |
22591243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kochi University |
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Principal Investigator |
YAMAMOTO Mayuko 高知大学, 教育研究部医療学系, 助教 (20423478)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Kimiko 高知大学, 教育研究部医療学系, 講師 (20403892)
TAKAISHI Mikiro 高知大学, 教育研究部医療学系, 助教 (10303223)
SANO Shigetoshi 高知大学, 教育研究部医療学系, 教授 (80273621)
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| Research Collaborator |
MAGATA Yasuhiro 浜松医科大学, 医学部, 教授
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| Project Period (FY) |
2010 – 2012
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| Keywords | 関節症性乾癬 |
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| Research Abstract |
We crossed psoriasis model mice with autoimmune arthritis model mice, and found that the double transgenic mice spontaneously developed psoriatic skin lesion on the back, tail and legs. They also developed sausage-like swelling in the digits of hind feet from as early as 2 or 3 weeks of age at a high frequency up to 75%. Histologically, they demonstrated diffuse edema in the dermis as well as enthesitis, resembling human psoriatic arthritis. The digit lesions demonstrated increased transcriptional levels of Th17 and th1 cytokines.
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