2012 Fiscal Year Final Research Report
A study on cell therapy in the treatment of refractory woundsusing gene transferred macrophages
| Project/Area Number |
22591248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAKENAKA Hideya 京都府立医科大学, 医学研究科, 准教授 (80254358)
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| Co-Investigator(Kenkyū-buntansha) |
ASAI Jun 京都府立医科大学, 医学研究科, 助教 (50438222)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 皮膚炎症 / 再生学 |
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| Research Abstract |
We investigated the effects of hepatocyte growth factor gene transfer to macrophages of diabetic mice. These gene transferred macrophages showed promoted tube formation. We also investigated the roles of macrophages during wound healing in diabetic mice. Statin treatment promoted infiltration of macrophages in granulation tissues. These macrophages produced vascular endothelial growth factor C, which induces lymphatic vessel formation.
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Research Products
(1 results)
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[Journal Article] Topical simvastatin accelerates wound healing indiabetes by enhancing angiogenesis and lymphangiogenesis2012
Author(s)
J. Asai, H. Takenaka, S. Hirakawa, J. Sakabe, A. Hagura, S. Kishimoto, K. Maruyama, K. Kajiya, S. Kinoshita, Y. Tokura, N. Katoh
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Journal Title
Am J Pathol
Volume: 181
Pages: 2217-2224
DOI
Peer Reviewed
