2012 Fiscal Year Final Research Report

A study on cell therapy in the treatment of refractory woundsusing gene transferred macrophages

Research Project

Project/Area Number	22591248
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Dermatology
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	TAKENAKA Hideya 京都府立医科大学, 医学研究科, 准教授 (80254358)
Co-Investigator(Kenkyū-buntansha)	ASAI Jun 京都府立医科大学, 医学研究科, 助教 (50438222)
Project Period (FY)	2010 – 2012
Keywords	皮膚炎症 / 再生学
Research Abstract	We investigated the effects of hepatocyte growth factor gene transfer to macrophages of diabetic mice. These gene transferred macrophages showed promoted tube formation. We also investigated the roles of macrophages during wound healing in diabetic mice. Statin treatment promoted infiltration of macrophages in granulation tissues. These macrophages produced vascular endothelial growth factor C, which induces lymphatic vessel formation.