2012 Fiscal Year Final Research Report
Intracellular parasitization of Mycobacterium leprae and development of leprosy
| Project/Area Number |
22591253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ISHII Norihisa 国立感染症研究所, ハンセン病研究センター, センター長 (50159670)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Koichi 国立感染症研究所, ハンセン病研究センター感染制御部, 室長 (20206478)
MORI Syuichi 国立感染症研究所, ハンセン病研究センター感染制御部, 室長 (40559522)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ハンセン病 / らい菌 / 細胞内寄生 |
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| Research Abstract |
Upon infection, Mycobacterium leprae (M. leprae), a causative agent of leprosy, modulates expression and localization of host proteins necessary for inhibition of phagosome-lysosome fusion, and for lipid accumulation or catabolism to create cellular microenvironment that is favorable for its intracellular parasitization. Only live M. leprae, but not heat-killed M. leprae had such effects. One of the drugs used to treat leprosy, clofazimine, suppressed such effects of M. leprae.
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[Journal Article] Detection of Mycobacterium leprae DNA from archaeological skeletal remains in Japan using whole genome amplification and polymerase chain reaction.2010
Author(s)
Suzuki K, Takigawa W, Tanigawa K, Nakamura K, Ishido Y, Kawashima A, Wu H, Akama T, Sue M, Yoshihara A, Mori S, Ishii N
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Journal Title
PLoS ONE
Volume: 5
Pages: e12422
DOI
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[Book] Whole genome tiling array analysis of bacterial genome. Chapter7 (Campbell MJ (Eds): DNA Microarrays, Synthesis and Synthetic DNA.)2011
Author(s)
Akama T, Tanigawa K, Nakamura K, Kawashima A, Wu H, Sue M, Yoshihara A, Ishido Y, Ishii N, Suzuki K
Total Pages
301-315
Publisher
Nova Science Publishers, Hauppauge
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