2012 Fiscal Year Final Research Report
Genome-wide association study of panic disorder in the Japanese population.
| Project/Area Number |
22591256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Tsukasa 東京大学, 教育学研究科, 教授 (50235256)
OTOWA Kenji 東京大学, 医学部附属病院, 助教 (70456119)
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| Project Period (FY) |
2010 – 2012
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| Keywords | Panic Disorder, GWAS, SNP |
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| Research Abstract |
In this study, we conducted a genome-wide association study (GWAS) in two independent data sets using the Affymetrix Mapping 500K Array or Genome-Wide Human SNP Array 6.0. We obtained imputed genotypes for each GWAS and performed a meta-analysis of two GWAS data sets (718 cases and 1717 controls). For follow-up, 12 single-nucleotide polymorphisms (SNPs) were tested in 329 cases and 861 controls. Gene ontology enrichment and candidate gene analyses were conducted using the GWAS or meta-analysis results. We also applied the polygenic score analysis to our two GWAS samples to test the hypothesis of polygenic components contributing to PD. Our findings suggest that large sets of common variants of small effects collectively account for risk of PD.
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