search for biomarker relatedto suicidalbehavior by metabolome analysis

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591261
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kobe University
• Principal Investigator: SASADA Toru 神戸大学, 大学院・医学研究科, 助教 (70457084)
• Co-Investigator(Kenkyū-buntansha): HISHIMOTO Akitoyo 神戸大学, 大学院・医学研究科精神医学分野, 講師 (50529526)
• Project Period (FY): 2010 – 2012
• Keywords: 臨床精神分子遺伝学

Research Abstract

Since it was expected that heterogeneity in "depressed state" was large, first of all, we focused on the schizophrenia group. Several literatures reported there was an association between low cholesterolemia and impulsivity.In our study, between suicide and non-suicide attempt group, a significant difference was notseen by the serum total cholesterol level and positive symptoms (conceptual disorganization, hostility and excitement), negative symptoms,and anxiety and depression of PANSS. On the other hand, in the suicide attempt group, the male's serum total cholesterol level was low as compared with the woman, and the psychiatric manifestation suited the high tendency generally. We are going to continue the analysis to multi-biomarker searchby means of metabolome analys and examine about the possibility of early picking up ofsuicide risk, and suicide re-plan prevention in psychiatric disorder patients.

Research Products

• [Journal Article] A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients. (2013)
  • Author(s): Supriyanto I, Watanabe Y, Mouri K, Shiroiwa K, Ratta-Apha W, Yoshida M, Tamiya G, Sasada T, Eguchi N, Okazaki K, Shirakawa O, Someya T, Hishimoto A.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 40 Pages: 347-52
  • DOI: DOI:10.1016/j.pnpbp.2012.11.002.Epub2012Nov12.
  • Peer Reviewed
• [Journal Article] Haplotypes in the expression quantitative trait locus of interleukin-1β gene are associated with schizophrenia (2012)
  • Author(s): Yoshida M, Shiroiwa K, Mouri K, Ishiguro H, Supriyanto I, Ratta-Apha W, Eguchi N, Okazaki S, Sasada T, Fukutake M, Hashimoto T, Inada T, Arinami T, Shirakawa O, Hishimoto A.
  • Journal Title: Schizophr Res Volume: 140(1-3) Pages: 185-91
  • DOI: DOI:10.1016/j.schres.2012.06.031.
  • Peer Reviewed
• [Journal Article] Association study of EP1 gene polymorphisms with suicide completers in the Japanese population (2011)
  • Author(s): Cui H, Supriyanto I, Sasada T, Shiroiwa K, Fukutake M, Shirakawa O, Asano M, Ueno Y, Nagasaki Y, Hishimoto A.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35(4) Pages: 1108-11
  • DOI: DOI:10.1016/j.pnpbp.2011.03.010
  • Peer Reviewed
• [Journal Article] Association of FKBP5 gene haplotypes with completed suicide in the Japanese population. (2011)
  • Author(s): Supriyanto I, Sasada T, Fukutake M, Asano M, Ueno Y, Nagasaki Y, Shirakawa O, Hishimoto A.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35(1) Pages: 252-6
  • DOI: DOI:10.1016/j.pnpbp.2010.11.019
  • Peer Reviewed
• [Presentation] 気分障害の併存を認めた発作性運動誘発性舞踏アテトーゼの 2 例. (2012)
  • Author(s): 笹田 徹
  • Organizer: 第108回日本精神神経学会学術総会.
  • Place of Presentation: 札幌
  • Year and Date: 2012-05-25
• [Presentation] Polymorphisms in a potential promoter region of the EP1 gene are associated with young suicide completers in the Japanese population. (2011)
  • Author(s): Akitoyo Hishimoto,Toru Sasada
  • Organizer: WFSBP Congress2011. Czechoslovakia
  • Year and Date: 20110500
• [Presentation] SSRI/SNRI 投与直後に自殺行動/念慮が惹起された5症例の検討 (2011)
  • Author(s): 笹田 徹
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-28
• [Book] 専門医のための精神科臨床リュミエール 29 自殺予防のための基本戦略(張賢徳編) (2011)
  • Author(s): 福武将映,菱本明豊,白川治
  • Total Pages: 24-34
  • Publisher: 中山書店
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/psyneu/newfolder1/index.html