2012 Fiscal Year Final Research Report
Biological study of obsessive-compulsive disorder using brain imaging and the molecular genetics
| Project/Area Number |
22591262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Tomohiro 九州大学, 大学病院, 講師 (50423554)
MITUYASU Hiroshi 九州大学, 大学病院, 助教 (00533176)
SANEMATSU Hirokuni 九州大学, 大学病院, 助教 (30588116)
YOSHIURA Takashi 九州大学, 医学研究科, 准教授 (40322747)
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| Co-Investigator(Renkei-kenkyūsha) |
KANBA Shigenobu 九州大学, 医学研究科, 教授 (50195187)
NAKAGAWA Akiko 千葉大学, 医学研究科, 教授 (70253424)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床精神分子遺伝学 |
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| Research Abstract |
Eighty-nine obsessive and compulsive disorder (OCD) patients and 89 healthy controls were genotyped with L- and s- types polymorphisms of 5HTT -LPR. As a result, OCD patients with current and/or past comorbid depression had a statistically higher frequency of the L-allele. The result suggested that the L-allele might be associated with the comorbidity depression with OCD.Magnetic resonance imaging examinations of 37 OCD patients and 37 healthy controls (HCs) were carried out. W e found significant reductions in right posterior cingulate cortexand some other areas in the OCD patients compared to healthy controls (HCs). In addition, we found specific correlations between the type of the obsession symptom and the volume of the specific area of the brain. The pathophysiology of OCD may involve widely distributed neural systems. Moreover, there are distinct correlations among symptomatic dimensions and structural abnormalities.
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Research Products
(15 results)
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[Journal Article] Predictors of treatment response to fluvoxamine in obsessive-compulsive disorder: An fMRI study2010
Author(s)
Sanematsu H, Nakao T, Yoshiura T, Nabeyama M, Togao O, Tomita M, Masuda Y, Yoshioka K, Nakatani E, Nakagawa A, Kanba S
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Journal Title
J Psychiatr Res
Volume: 44
Pages: 193-200
DOI
Peer Reviewed
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[Journal Article] Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: A voxel-based morphometry study2010
Author(s)
Togao O, Yoshiura T, Nakao T, Nabeyama M, Sanematsu H, Nakagawa A, Noguchi T, Hiwatashi A, Yamashita K, Nagao E, Kanba S, Honda H
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Journal Title
PsychiatryRes
Volume: 184
Pages: 29-37
DOI
Peer Reviewed
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[Presentation] Neural correlation between brain activities and clinical improvement in patients with checking symptom and patients with washing symptom in obsessive-compulsive disorder: an fMRI symptom provocation study2012
Author(s)
Murayama K, Nakao T, Sanenatsu H, Okada K, Yoshiura T, Tomita M, Matsuda Y, Isomura K, Nakagawa A, Kanba S
Organizer
Europian Association for Behavioural and Cognitive Therapies
Place of Presentation
Geneva, Switzerland
Year and Date
20120829-0901
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