2012 Fiscal Year Final Research Report

Prg1, regulated by MATH2, is an important factor for survival of neurons derived from neural stem cells

Research Project

Project/Area Number	22591268
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	National Center of Neurology and Psychiatry
Principal Investigator	YAMADA Misa 独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 科研費研究員 (10384182)
Co-Investigator(Kenkyū-buntansha)	SAITOH Akiyoshi 独立行政法人国立精神・神経医療研究センター, ・精神保健研究所精神薬理研究部, 室長 (00366832) YAMADA Mitsuhiko 独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 部長 (60240040)
Project Period (FY)	2010 – 2012
Keywords	精神薬理学 / 転写因子 / 遺伝子
Research Abstract	We determined that Prg1, the target gene of a transcription factor MATH2, was induced after chronic treatment with SSRI in mouse hippocampus. Immunohistochemistry revealed that Prg1 expressed in the mouse dentate gyrus and colocalized with NeuN (neuron marker). Then, we studied the role in neuronal survival in neurons derived from neural stem cells. Our results suggest that Prg1 is important for survival of neurons through dephosphorylation activity.

(3 results)