2012 Fiscal Year Final Research Report
Iintervention and discrimination of developmental disorders and prodromal state of psychosis in adolescents by biological methods
| Project/Area Number |
22591272
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hirosaki University |
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Principal Investigator |
SAITO Manabu 弘前大学, 医学部附属病院, 講師 (40568846)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKORI Norio 弘前大学, 医学(系)研究科(研究院), 准教授 (20333734)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 児童精神医学 |
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| Research Abstract |
Seventy four 12-18-year-old patients with prodromal state of psychosis (At Risk Mental State : ARMS) were investigated. 23% patients shifted to schizophrenia in observation 12 months after diagnosing as the risk state,.
Although 59% among 74 ARMS patients met the diagnostic criteria of pervasive developmental disorder (PDD), there was no difference in the transition rate to schizophrenia between PDD group and non-PDD group. Moreover, in the cognitive function inspection, BACS-J of forty ARMS patients, the transition group accepted the significant fall in the item of language memory (p< 0.05), cautions (p< 0.005), and Total score (p<0.05), respectively. Further, logistic regression analysis was performed for 90 ARMS patients' SIPS score. The odds ratio was 1.898 (p< 0.05) in P1; the unnatural content of thought / delusion, 0.411 (p< 0.05) in P3; the exaggerated idea and 4.203 (p< 0.01) in P4; the abnormalities of the consciousness / hallucination, and the more the score of P1 and P4 went up, the more a result with the increasing possibility of the onset of a disease was brought. In a biological index, it is under analysis about BDNF, EDA, and a micro RNA.
Since there is little consent patient load about (3) and (4), research is under continuation.
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[Journal Article] Prevalence of metabolic syndrome among patients with schizophrenia in Japan2010
Author(s)
Sugawara N, Yasui-Furukori N, Sato Y, Umeda T, Kishida I, Yamashita H, Saito M, Furukori H, Nakagami T, Hatakeyama M, Nakaji S, Kaneko S
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Journal Title
Schizophr Res
Volume: 123(2-3)
Pages: 244-50
DOI
Peer Reviewed
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