2012 Fiscal Year Final Research Report
Studies on the role of hippocampal glutamatergic system in cognitive function using hippocampal subregion-specific NMDA receptor knockout mice
| Project/Area Number |
22591274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
JINDE Seichiro 東京大学, 医学部附属病院, 講師 (30376454)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 精神生理学 |
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| Research Abstract |
In this study, a conditional NMDA receptor subunit 1 (NR1) knockout mouse strain, in which NR1 is selectively ablated in the hippocampal mossy cells by 12week of age, were subjected to histological and behavioral analyses to elucidate the functional role of mossy cells on cognition or emotion. This strain showed the reduced emotional reactivity and the decreased hippocampal neurogenesis. These results implicate thecrucial role of mossy cell NR1 in the maturation of newly generated dentate granule cells, which may regulate emotional behavior.
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