2013 Fiscal Year Final Research Report
Disease specificity of the brain morphologic changes in psychiatric disorders
| Project/Area Number |
22591275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Toyama |
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Principal Investigator |
TAKAHASHI Tsutomu 富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Michio 富山大学, 大学院医学薬学研究部(医学), 教授 (40236013)
KAWASAKI Yasuhiro 富山大学, 大学病院, 講師 (80242519)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 精神生理学 / 脳画像診断学 / 統合失調症 / 磁気共鳴画像 |
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| Research Abstract |
In this study, we used magnetic resonance imaging to investigate the disease specificity of brain morphologic changes in schizophrenia. Gray matter reduction in the superior temporal and anterior cingulate gyri existed prior to the onset of schizophrenia. Progressive gray matter loss in the temporal region during early stages was specific to schizophrenia among various psychiatric disorders. However, enlarged pituitary volume, which might reflect stress vulnerability, and alteration in the olfactory sulcus depth, a potential neurodevelopmental marker, were general findings among several neuropsychiatric disorders.
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