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2012 Fiscal Year Final Research Report

Neuroimaging studies on cognitive function in schizophrenia

Research Project

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Project/Area Number 22591278
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Fukui

Principal Investigator

WADA Yuji  福井大学, 医学部附属病院, 教授 (30175153)

Co-Investigator(Renkei-kenkyūsha) MURATA Tetsuhito  福井大学, 医学部, 准教授(H22-H23) (80200294)
TAKAHASHI Tetsuya  福井大学, 医学部附属病院, 講師 (00377459)
KOSAKA Hirotaka  福井大学, 子どものこころの発達研究センター, 特命准教授 (70401966)
Project Period (FY) 2010 – 2012
Keywords精神生理学 / 統合失調症
Research Abstract

We performed a series of studies to explore the pathophysiology underlying cognitive dysfunction in schizophrenia. In a non-linear EEG analysis, patients showed higher complexity at higher time scales than healthy controls over the fronto-temporal regions. Secondly, we investigated amygdala responses during facial recognition using a functional magnetic resonance imaging; Schizophrenia patients showed more prominent activation of the right amygdala than controls. In contrast, individuals with high-functioning autism spectrum disorders showed less amygdala activity than controls during facial recognition task. Finally, we assessed the effects of tandospirone, a serotonin-1A partial agonist, and found the improvement of frontal cognitive dysfunction of patients detected by Cambridge Neuropsychological Test Automated Battery.

  • Research Products

    (2 results)

All 2012 2010

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] Antipsychotics reverse abnormal EEGcomplexity in drug-naive schizophrenia: a multiscale entropy analysis2010

    • Author(s)
      T .Takahashi, RY.Cho, T.Mizuno, M.Kikuchi, T.Murata, K.Takahashi, Y.Wada
    • Journal Title

      Neuroimage

      Volume: 51(1) Pages: 173-82

  • [Presentation] 5-HT1Aアゴニスト(タンドスピロン)にて認知機能の改善を認めた統合失調症の二例-CANTABによる検討2012

    • Author(s)
      岡崎玲子, 西本武史, 高橋哲也, 小坂浩隆, 石飛 信, 水野智之, 村田哲人, 和田有司
    • Organizer
      第108回日本精神神経学会学術総会
    • Year and Date
      2012-05-24

URL: 

Published: 2014-08-29  

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