2012 Fiscal Year Final Research Report

Molecular imaging study on dopaminergic system in autism: in relation to deficits in memory reconstruction

Research Project

Project/Area Number	22591280
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	TAKAGAI Shu 浜松医科大学, 子どものこころの発達研究センター, 准教授 (10447807)
Co-Investigator(Kenkyū-buntansha)	NAKAMURA Kazuhiko 弘前大学, 医学系研究科, 教授 (80263911) SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040) IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025) OUSHI Yasuomi 浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978) TAKEBAYASHI Kiyokazu 浜松医科大学, 医学部附属病院, 講師 (50397428) MORI Norio 浜松医科大学, 医学部, 教授 (00174376)
Project Period (FY)	2010 – 2012
Keywords	児童 / 思春期精神医学 / 分子イメージング / ドパミン系 / PET / 自閉症
Research Abstract	Using positron emission tomography (PET), we measured the binding of brain dopamine D1 receptors in fifteen men with high-functioning autism and 15 age- and IQ-matched control subjects with the radioligand [11C]SCH23390. Statistical parametric mapping was used for between-subject analysis and within-subject correlation analysis withrespect to clinical variables.Analyses are still ongoing.