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2012 Fiscal Year Final Research Report

Mass spectrometry analysis of human cerebrospinal fluid with psychiatric disease patients.

Research Project

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Project/Area Number 22591284
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

OKOCHI Masayasu  大阪大学, 医学系研究科, 講師 (90335357)

Co-Investigator(Kenkyū-buntansha) TAGAMI Shinji   (40362735)
TAKEDA Masatoshi   (00179649)
Project Period (FY) 2010 – 2012
Keywords精神神経疾患 / 質量分析法 / 脳脊髄液
Research Abstract

By using LC/MS/MS analysis, we tried to detect brain peptides which are associated with psychiatric disorders. We used CSF of patients with or withoutpsychiatric disorders. We detected and compared the levels of more than a thousand of peptides of which amino-acid sequences were determined by us. However, we could not successfully detect any specific peptides, so far . We will continue the study to find endogenous compounds which are associated with psychiatric conditions.

  • Research Products

    (27 results)

All 2013 2012 2011 2010

All Journal Article (17 results) Presentation (10 results)

  • [Journal Article] γ -secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ432013

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takami M,Kodama TS, Mori K, Nakayama T, Ihara Y,Takeda M
    • Journal Title

      Cell Rep

      Volume: 3 Pages: 42-51

  • [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia.2013

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M.
    • Journal Title

      World J Biol Psychiatry

      Volume: 14 Pages: 100-13

  • [Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs2012

    • Author(s)
      Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R.
    • Journal Title

      PLoS One

      Volume: 7

  • [Journal Article] Non-pharmacological intervention for dementia patients.2012

    • Author(s)
      Takeda M, Tanaka T, Okochi M, Kazui H
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66 Pages: 1-7

  • [Journal Article] Involvement of endoplasmic reticulum stress in tauopathy.2011

    • Author(s)
      Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 430 Pages: 500-4

  • [Journal Article] [Behavioral and psychological symptoms of dementia]2011

    • Author(s)
      Okochi M, Takeda M
    • Journal Title

      Nihon Rinsho.

      Volume: 8 Pages: 308-12

  • [Journal Article] PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.2011

    • Author(s)
      Sigma-1Rs are upregulated via Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 415 Pages: 519-25

  • [Journal Article] New drugs for Alzheimer's disease in Japan2011

    • Author(s)
      Takeda M, Tanaka T, Okochi M.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 65 Pages: 399-404

  • [Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011

    • Author(s)
      Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Psychogeriatrics

      Volume: 11 Pages: 90-7

  • [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population.2011

    • Author(s)
      Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
    • Journal Title

      World J Biol Psychiatry

      Volume: 11 Pages: 852-7

  • [Journal Article] Apolipoprotein E and central nervous system disorders: reviews of clinical findings.2010

    • Author(s)
      Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 64 Pages: 592-607

  • [Journal Article] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.2010

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet.

      Volume: 153 Pages: 1459-64

  • [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010

    • Author(s)
      Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T
    • Journal Title

      Dement Geriatr Cogn Disord.

      Volume: 30 Pages: 302-8

  • [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010

    • Author(s)
      Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, FujiiK, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Take da M.
    • Journal Title

      Psychogeriatrics.

      Volume: 10 Pages: 117-23

  • [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010

    • Author(s)
      Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 14920-31

  • [Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients.2010

    • Author(s)
      Okochi M, Tagami S, Takeda M
    • Journal Title

      Neurodegener Dis.

      Volume: 7 Pages: 42-5

  • [Journal Article] The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.2010

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S
    • Journal Title

      Schizophr Res.

      Volume: 116 Pages: 126-32

  • [Presentation] Potential Action Mechanism of γ-Secretase Modulators2013

    • Author(s)
      Okochi M
    • Organizer
      AD/PD2013
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2013-10-06
  • [Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際2012

    • Author(s)
      大河内 正康 田上 真次 柳田 寛太児玉 高志 武田 雅俊
    • Organizer
      第31回日本認知症学会学術集会 トピックス徹底討論「抗 Ab 療法の最新現状と徹底討論」
    • Place of Presentation
      つくば国際会議場、第4 会場 2F 中ホール
    • Year and Date
      2012-10-28
  • [Presentation] アルツハイマー病発症前診断バイオマーカーの開発 脳プロ課題 F ・アミロイドβ42 産生の上流機構の解析(武田班)2012

    • Author(s)
      大河内正康 田上 真次 朝長毅 武田雅俊
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      会場:E 会場(神戸国際会議場502)
    • Year and Date
      2012-09-30
  • [Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP22012

    • Author(s)
      Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
    • Organizer
      Alzheimer's Association International Conference 2012
    • Place of Presentation
      Vancouver Convention & Exhibition Centre, Vancouver Canada
    • Year and Date
      2012-07-18
  • [Presentation] S15-4 認知症バイオマーカーと次世代認知症治療戦略2011

    • Author(s)
      大河内正康
    • Organizer
      第21回日本臨床精神神経薬理学会, 第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      第2 会場(コンコード B)シンポジウム 15 認知症の病態理解から診断・治療法へ
    • Year and Date
      2011-10-27
  • [Presentation] Biochemistry of "Ab-like Peptide", a novel type of peptide family2011

    • Author(s)
      Masayasu Okochi
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-07-24
  • [Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab422011

    • Author(s)
      Masayasu Okochi
    • Organizer
      AAICAD2011
    • Place of Presentation
      Paris Porte de Versailles, Convention and Exhibition Center, France
    • Year and Date
      2011-07-21
  • [Presentation] Session Title: A Return to the Basics- Molecular Decoding of the Alzheimer's Disease Pathogenesis""アルツハイマー病治療薬γセクレターゼ・モジュレーターの理論とその将来的優位性について2011

    • Author(s)
      大河内正康
    • Organizer
      第33回生物学的精神医学会
    • Place of Presentation
      シンポジウム2・アルツハイマー病治療薬の新たな展開 ホテルグランパシフィック LE DAIBA・パレロワイヤル B
    • Year and Date
      2011-05-21
  • [Presentation] Aβ様ペプチドの分泌から見えること-Aβ産生過程の発症への関与の可能性2010

    • Author(s)
      大河内正康
    • Organizer
      第29回日本認知症学会・シンポジウム 7
    • Place of Presentation
      名古屋ウインク愛知・第2 会場
    • Year and Date
      2010-11-06
  • [Presentation] New aspects of pathophysiology and therapeutic/diagnostic strategy of dementia The ratio of CSF APL1beta28, a surrogate marker for Abeta422010

    • Author(s)
      Masa Okochi
    • Organizer
      increases before onset of sporadic Alzheimer diseaseICAD2010
    • Place of Presentation
      Hawaii Convention Center,Honolulu, Hawaii. Oral session
    • Year and Date
      2010-07-14

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Published: 2014-08-29  

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