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2013 Fiscal Year Final Research Report

An epidemiological study on relation between sleep problems and depression

Research Project

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Project/Area Number 22591301
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNihon University

Principal Investigator

UCHIYAMA Makoto  日本大学, 医学部, 教授 (20221111)

Co-Investigator(Kenkyū-buntansha) KONNO Michiko  日本大学, 医学部, 講師 (90282053)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywordsうつ病 / 不眠 / 睡眠習慣 / QOL / 睡眠不足 / 入眠障害 / 中途覚醒 / 早朝覚醒
Research Abstract

We aimed to clarify the association between depression and sleep disturbances among Japanese general adult population. Data from 2,532 individuals from Japanese general adult population were analyzed. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess the prevalence of depression. The prevalence of depression was estimated to be 6.0% (men 5.1%, and women 6.7%). The prevalence of difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), and early morning awakenings (EMA) was 14.8%, 26.6%, and 11.7%, respectively, and 32.7% of the sample reported at least one of them. DIS, EDS, and IRS were independently associated with poor perceived mental health status. Both short sleep duration (<6 h) and short TIB (<6 h) were significantly associated with symptoms of depression. We postulate that TIB, a modifiable sleep habit, may be an important target for improvement of sleep hygiene as a means of preventing depression.

  • Research Products

    (60 results)

All 2014 2013 2012 2011 2010

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (20 results) Book (20 results)

  • [Journal Article] Abdominal paresthesia resembling restless legs syndrome successfully treated with iron supplement therapy: A case report2014

    • Author(s)
      Suzuki M, Yamada K, Kanamori T, Konno C, Konno M, Takahashi S, Aramaki O, Takayama T, Uchiyama M
    • Journal Title

      J Neurol Sci

      Volume: 336 Pages: 291-2

    • Peer Reviewed
  • [Journal Article] Sleep/wake patterns and circadian typology in preschool children based on standardized parental self-reports2014

    • Author(s)
      Doi Y, Ishihara K, Uchiyama M
    • Journal Title

      Chronobiol Int

      Volume: 31 Pages: 328-336

    • Peer Reviewed
  • [Journal Article] A Cross-sectional Study of the Association between Working Hours and Sleep Duration among the Japanese Working Population2013

    • Author(s)
      Ohtsu T, Kaneita Y, Aritake S, Mishima K, Uchiyama M, Akashiba T, Uchimura N, Nakaji S, Munezawa T, Kokaze A, Ohida T
    • Journal Title

      J Occup Health

      Volume: 55 Pages: 307-311

    • Peer Reviewed
  • [Journal Article] Relationship between quantitative electro -encephalogram and interferon-α induced depression in chronic hepatitis C patients2013

    • Author(s)
      Morita A, Kamei S, Sakai T, Oga K, Matsuura M, Kojima T, Uchiyama M, Tanaka N, Arakawa Y, Moriyama M
    • Journal Title

      Neuropsychobiology

      Volume: 67 Pages: 122-126

    • Peer Reviewed
  • [Journal Article] A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden2013

    • Author(s)
      Takahashi S, Suzuki M, Uchiyama M
    • Journal Title

      J Neuropsychiatry Clin Neurosci

      Volume: 25 Pages: E28

    • Peer Reviewed
  • [Journal Article] Alpha activity during rem sleep contributes to overnight improvement in performance on a visual discrimination task2012

    • Author(s)
      Suzuki H, Uchiyama M, Aritake S, Kuriyama K, Kuga R, Enomoto M, Mishima K
    • Journal Title

      Percept Mot Skills

      Volume: 115 Pages: 337-48

    • Peer Reviewed
  • [Journal Article] A randomized placebo-controlled polysomnographic study of eszopiclone in Japanese patients with primary insomnia2012

    • Author(s)
      Uchimura N, Kamijo A, Kuwahara H, Uchiyama M, Shimizu T, Chiba S, Inoue Y
    • Journal Title

      Sleep Med A

      Volume: 13(10) Pages: 1247-53

    • Peer Reviewed
  • [Journal Article] The association between sleep problems and perceived health status: A Japanese nationwide general population survey2012

    • Author(s)
      Furihata R, Uchiyama M, Takahashi S, Suzuki M, Konno C, Osaki K, Konno M, Kaneita Y, Ohida T, Akahoshi T, Hashimoto S, Akashiba T
    • Journal Title

      Sleep Medicine

      Volume: 13 Pages: 831-837

    • Peer Reviewed
  • [Journal Article] Preferable Forms of Relaxation for Health Promotion, and the Association between Recreational Activities and Self-perceived Health2012

    • Author(s)
      Ohtsu T, Kaneita Y, Aritake S, Mishima K, Uchiyama M, Akashiba T, Uchimura N, Nakaji S, Munezawa T, Shimada N, Kokaze A, Ohida T
    • Journal Title

      Acta Med Okayama

      Volume: 66 Pages: 41-51

    • Peer Reviewed
  • [Journal Article] Relationships between exploratory eye movement dysfunction and clinical symptoms in schizophrenia2012

    • Author(s)
      Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66(3) Pages: 187-94

    • Peer Reviewed
  • [Journal Article] Chronic insomnia, quality-of-life, and utility scores: Comparison with good sleepersin a cross-sectional international survey2012

    • Author(s)
      Léger D, Morin CM, Uchiyama M, Hakimi Z, Cure S, Walsh JK
    • Journal Title

      Sleep Med

      Volume: 13 Pages: 43-51

    • Peer Reviewed
  • [Journal Article] Clinical significance and management of insomnia2011

    • Author(s)
      Uchiyama M, Inoue Y, Uchimura N, Kawamori R, Kuribayashi M, Kario K, Watada H
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 9 Pages: 63-72

    • Peer Reviewed
  • [Journal Article] Self-help behaviors for sleep and depression: A Japanese nationwide general population survey2011

    • Author(s)
      Furihata R, Uchiyama M, Takahashi S, Konno C, Suzuki M, Osaki K, Kaneita Y, Ohida T
    • Journal Title

      J Affect Disord

      Volume: 130 Pages: 75-82

    • Peer Reviewed
  • [Journal Article] Long-term safety and efficacy of ramelteon in Japanese patients with chronicinsomnia2011

    • Author(s)
      Uchiyama M, Hamamura M, Kuwano T, Nagata H, Hashimoto T, Ogawa A, Uchimura N
    • Journal Title

      Sleep Med

      Volume: 12 Pages: 127-33

    • Peer Reviewed
  • [Journal Article] Evaluation of subjective efficacy and safety of ramelteon in Japanese subjects with chronic insomnia2011

    • Author(s)
      Uchiyama M, Hamamura M, Kuwano T, Nishiyama H, Nagata H, Uchimura N
    • Journal Title

      Sleep Med

      Volume: 12 Pages: 119-26

    • Peer Reviewed
  • [Journal Article] Efficacy and safety of ramelteon in Japanese adults with chronic insomnia: a randomized, double-blind, placebo-controlled study2011

    • Author(s)
      Uchimura N, Ogawa A, Hamamura M, Hashimoto T, Nagata H, Uchiyama M
    • Journal Title

      Expert Rev. Neurother

      Volume: 11 Pages: 215-224

    • Peer Reviewed
  • [Journal Article] Hidden harm2011

    • Author(s)
      Suzuki M, Konno C, Takahashi S, Uchiyama M
    • Journal Title

      Lancet

      Volume: 377 Pages: 874

    • Peer Reviewed
  • [Journal Article] Hyperprolactinemia in Psychiatric Patients Treated with Antipsychotics: 24 Case Reports2010

    • Author(s)
      Takahashi S, Suzuki M, Uchiyama M
    • Journal Title

      The Nihon University Journal of Medicine

      Volume: 52 Pages: 27-36

    • Peer Reviewed
  • [Journal Article] Association between depression and insomnia subtypes: a longitudinal study on the elderly in Japan2010

    • Author(s)
      Yokoyama E, Kaneita Y, Saito Y, Uchiyama M, Matsuzaki Y, Tamaki T, Munezawa T, Ohida T
    • Journal Title

      Sleep

      Volume: 33 Pages: 1693-702

    • Peer Reviewed
  • [Journal Article] Diurnal fluctuations in subjective sleep time in humans2010

    • Author(s)
      Aritake-Okada S, Higuchi S, Suzuki H, Kuriyama K, Enomoto M, Soshi T, Kitamura S, Watanabe M, Hida A, Matsuura M, Uchiyama M, Mishima K
    • Journal Title

      Neurosci Res

      Volume: 66 Pages: 225-231

    • Peer Reviewed
  • [Presentation] 概日リズム睡眠障害の病態生理. トピックス, 概日リズムと循環器疾患2014

    • Author(s)
      内山真, 金野倫子, 鈴木正泰
    • Organizer
      第78回日本 循環器学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-21
  • [Presentation] こころとからだとよい眠り2013

    • Author(s)
      内山真
    • Organizer
      第42回日本女性心身医学会学術集会 市民公開講座「女性とこころとからだの健康」
    • Place of Presentation
      東京
    • Year and Date
      2013-07-27
  • [Presentation] 不眠と夜間頻尿2013

    • Author(s)
      内山真
    • Organizer
      第101回日 本泌尿器科学会総会サテライトセミナー 病因に基づく夜間頻尿治療
    • Place of Presentation
      札幌
    • Year and Date
      2013-04-27
  • [Presentation] 睡眠脳波の見方と生理学的背景2012

    • Author(s)
      内山真
    • Organizer
      第42回日本臨床神経生理学会学術大会
    • Place of Presentation
      東京 (教育講演)
    • Year and Date
      2012-11-10
  • [Presentation] 頻度の高い睡眠障害の薬物治療2012

    • Author(s)
      内山真
    • Organizer
      CNP 臨床精神神経薬理学セミナー, 第22回日本臨床精神神経薬理学会・第42 回日本神経精神薬理学会合同年会
    • Place of Presentation
      宇都宮
    • Year and Date
      2012-10-19
  • [Presentation] うつ病における概日リズムの異常について2012

    • Author(s)
      金野倫子, 鈴木正泰, 内山真
    • Organizer
      シンポジウム「精神疾患の時間生物学」 第19回時間生物学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-15
  • [Presentation] うつ病と睡眠障害の関連2012

    • Author(s)
      鈴木正泰, 内山真
    • Organizer
      シンポジウム 第9回うつ病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-28
  • [Presentation] 睡眠習慣と不眠の関係2012

    • Author(s)
      金野倫子, 内山真
    • Organizer
      シンポジウム24「不眠症と人間生活の相互関係」, 日本睡眠学会第37回定期学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-29
  • [Presentation] 睡眠と体温2012

    • Author(s)
      内山真
    • Organizer
      第33回温泉療法医学会 教育研修会市民セミナー
    • Place of Presentation
      仙北
    • Year and Date
      2012-06-09
  • [Presentation] うつ病と不眠の関連に関する最新の知見とうつ病治療への応用2011

    • Author(s)
      内山真
    • Organizer
      第107回 日本精神神経学会総会
    • Place of Presentation
      東京 (教育講演)
    • Year and Date
      2011-10-26
  • [Presentation] Circadian pathology and chronobiotic treatment of chronic circadian rhythm disorders2011

    • Author(s)
      Uchiyama M
    • Organizer
      Symposium: Symposium 3 Human Circadian ClockInternational Symposium on Photonic Bioimaging, Satellite Symposium of World Sleep 2011 on Human Circadian Clock: The 50th Anniversary of Temporal Isolation Study
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2011-10-23
  • [Presentation] Anthropology of one's sleepless nights2011

    • Author(s)
      Uchiyama M
    • Organizer
      Luncheon Seminar. Worldsleep2011
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-10-17
  • [Presentation] Making Japanese consensus report on the management of insomnia in general practice2011

    • Author(s)
      Uchiyama M
    • Organizer
      Symposium: Current update on the strategy for diagnosis and treatment of chronic insomnia. Worldsleep2011
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-10-16
  • [Presentation] Melatonin and melatonin receptor agonist in the treatment of circadian rhythm sleep disorders2011

    • Author(s)
      Uchiyama M
    • Organizer
      Symposium: Multifacet actions of melatonin and melatonin receptor agonists on human sleep. Worldsleep2011
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-10-16
  • [Presentation] 不眠症の慢性化と睡眠薬服用の長期化に関与する要因2011

    • Author(s)
      内山真
    • Organizer
      シンポジウム睡眠薬の適正化に向けて, 第36回日本睡眠学会
    • Place of Presentation
      京都
    • Year and Date
      2011-10-15
  • [Presentation] 睡眠を科学する2011

    • Author(s)
      内山真
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      福井市
    • Year and Date
      2011-09-16
  • [Presentation] 網膜で受けた光の心と身体への影響: シンポジウム4 光のゆらぎと現代病, 光療法の新たな可能性をみすえて2010

    • Author(s)
      内山真
    • Organizer
      第17回日本時間生物学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-20
  • [Presentation] オレキシン受容体拮抗薬による睡眠障害治療: シンポジウム5 睡眠薬の現状と今後の展望2010

    • Author(s)
      内山真
    • Organizer
      第20回日本臨床精神神経薬理学会 第40 回日本神経精神薬理学会 合同年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-15
  • [Presentation] 精神疾患にみられる不眠・過眠とその対応:シンポジウム 精神疾患に併存する睡眠障害の診断と治療2010

    • Author(s)
      内山真
    • Organizer
      第106回日本精神神経学会学術総会
    • Place of Presentation
      広島
    • Year and Date
      2010-05-22
  • [Presentation] 専門医を目指す人の特別講座: 精神科臨床に必要な睡眠医学の知識2010

    • Author(s)
      内山真
    • Organizer
      第106回日本精神神経学会学術総会
    • Place of Presentation
      広島
    • Year and Date
      2010-05-20
  • [Book] 睡眠のはなし – 快眠のためのヒント2014

    • Author(s)
      内山真
    • Publisher
      中央公論, (東京)
  • [Book] Non–24-h sleep–wake disorder (free-running type, nonentrained type, hypernychthemeral syndrome) in sighted and blind patients, (The Encyclopedia of Sleep)(ed. Kushida CA)2013

    • Author(s)
      Lockley SW, Uchiyama M
    • Total Pages
      34-40
    • Publisher
      (Chicago, USA)
  • [Book] G 光療法, 認知症ハンドブック2013

    • Author(s)
      内山真
    • Total Pages
      287-293
    • Publisher
      株式会社 医学書院, (東京)
  • [Book] 「眠れません……」を解決する不眠症診療&マネジメントマニュアル ―7つの主訴でわかる! 10の問診でわかる! 睡眠薬の使いどき・やめどきがわかる!2013

    • Author(s)
      内山真
    • Publisher
      株式会社メディカ出版, (大阪)
  • [Book] 過眠症(ナルコレプシーを含む), 今日の治療指針2013 年版2013

    • Author(s)
      内山真 他
    • Total Pages
      891
    • Publisher
      (株)医学書院, (東京)
  • [Book] 睡眠障害の診断, 千葉茂編: 脳とこころのプライマリケア 5意識と睡眠2012

    • Author(s)
      内山真
    • Total Pages
      398-410
    • Publisher
      シナジー, (東京)
  • [Book] 睡眠障害の対応と治療ガイドライン2012

    • Author(s)
      内山真
    • Publisher
      じほう (編集), (東京)
  • [Book] 睡眠障害(不眠症)[Sleep disorder(Insomnia)], わかりやすい疾患と処方箋の解説2012 年版〔病態・薬物治療編〕2012

    • Author(s)
      内山真
    • Total Pages
      93-97
    • Publisher
      アークメディア, (東京)
  • [Book] 不眠症, 研修ノートシリーズ精神科研修ノート2011

    • Author(s)
      内山真
    • Total Pages
      375-379
    • Publisher
      診断と治療社, (東京)
  • [Book] 概日リズム睡眠障害(CRSD), 睡眠障害診療ガイド2011

    • Author(s)
      内山真, (日本睡眠学会 認定委員会睡眠障害診療ガイド・ワーキンググループ監修)
    • Total Pages
      60-68
    • Publisher
      文光堂, (東京)
  • [Book] 月経関連睡眠障害 , 精神医学キーワード事典2011

    • Author(s)
      内山真, (松下正明 総編, 伊豫正臣・内山 真・内海 健・笠井清登・加藤 敏・神庭重信・齊藤万比古・佐野 輝・藤山直樹 編)
    • Total Pages
      327-329
    • Publisher
      中山書店, (東京)
  • [Book] 精神疾患と睡眠障害, 精神医学キーワード事典2011

    • Author(s)
      内山真, (松下正明 総編,伊豫正臣・内山 真・内海 健・笠井清登・加藤 敏・神庭重信・齊藤万比古・佐野 輝・藤山直樹 編)
    • Total Pages
      338-342
    • Publisher
      中山書店, (東京)
  • [Book] 睡眠薬(ベンゾジアゼピン受容体作動薬とメラトニン受容体作動薬), 精神医学キーワード事典2011

    • Author(s)
      内山真, (松下正明 総編, 伊豫正臣・内山 真・内海 健・笠井清登・加藤 敏・神庭重信・齊藤万比古・佐野 輝・藤山直樹編)
    • Total Pages
      636-640
    • Publisher
      中山書店, (東京)
  • [Book] ぐっすり眠って、すっきり起きよう!今度こそ「快眠」できる13 の方法2011

    • Author(s)
      内山真
    • Publisher
      阪急コミュニケーションズ, (東京)
  • [Book] 生物学的治療 C 睡眠薬, 専門医をめざす人の精神医学 第3 版2011

    • Author(s)
      内山真, (山内俊雄・小島卓也・倉知正佳・鹿島晴雄 編)
    • Total Pages
      624-631
    • Publisher
      医学書院, (東京)
  • [Book] 非器質性睡眠障害 2.睡眠覚醒スケジュール障害に対する有効な治療は? , EBM 精神疾患の治療2011-20122011

    • Author(s)
      内山真
    • Total Pages
      206-212
    • Publisher
      中外医学社, (東京)
  • [Book] 生体リズムと眠気, 眠気の科学 ―そのメカニズムと対応―(井上雄一,林 光緒 編)2011

    • Author(s)
      内山真
    • Total Pages
      81-87
    • Publisher
      朝倉書店, (東京)
  • [Book] 睡眠障害とうつ病, うつ病治療ハンドブック ―診療のコツ―2011

    • Author(s)
      内山真, (大野 裕 編)
    • Total Pages
      149-158
    • Publisher
      金剛出版, (東京)
  • [Book] 睡眠の病気 不眠症・睡眠時無呼吸・むずむず脚, 別冊NHK きょうの健康2011

    • Author(s)
      内山真
    • Publisher
      NHK出版, (東京)
  • [Book] 「眠る力」を呼び戻す!名医が教える不眠症に打ち克つ本2010

    • Author(s)
      内山真
    • Publisher
      アーク出版, (東京)

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Published: 2015-07-16   Modified: 2015-07-29  

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