Changes in Regional Myocardial Oxidative Metabolism and MyocardialBlood Flow in Patients with Cardiac Resynchronization Therapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: CHIBA Satoru 北海道大学, 北海道大学病院, 医員 (40553368)
• Co-Investigator(Kenkyū-buntansha): TSUTSUI Hiroyuki 北海道大学, 大学院・医学研究科, 教授 (70264017) ; YOKOSHIKI Hisashi 北海道大学, 北海道大学病院, 講師 (40360911) ; YAMADA Satoshi 北海道大学, 北海道大学病院, 講師 (80374320) ; YOSHINAGA Keiichirou 北海道大学, 大学院・医学研究科, 教授 (30435961) ; KATOU Chietsugu 北海道大学, 保健科学院, 教授 (10292012)
• Project Period (FY): 2010 – 2012
• Keywords: 酢酸 PET / 心筋酸素代謝 / 心臓再同期療法

Research Abstract

Cardiac resynchronization therapy (CRT) can induce reversing left ventricular (LV) remodeling and improve the abnormalities in the perfusion and metabolism in patients with heart failure (HF). Acetate positron emission tomography (PET) could provide biologic information about the myocardium at both regional and global levels. We test the hypothesis that CRT can decrease LV volume and improve myocardial oxidative metabolism as well as LV volume in HF patients. CRT induced reverse LV remdeling in patients with HF, which was associated with a reduction in heterogenous oxidative metabolism.

Research Products

• [Journal Article] Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction (2013)
  • Author(s): Chiba S, Naya M, Iwano H, Yoshinaga K, Katoh C, Manabe O, Yamada S, Wakasa S, Kubota S, Matsui Y, Tamaki N, Tsutsui H
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 40(3) Pages: 349-55
  • Peer Reviewed
• [Journal Article] Cardiac (18)F-FDG PET/CT with heparin detects infective vegetation in a patient with mechanical valve replacement (2012)
  • Author(s): Klaipetch A, Manabe O, Oyama- Manabe N, Chiba S, Naya M, Yamada S, Hirata K, Tsutsui H, Tamaki N
  • Journal Title: Clin Nucl Med Volume: 37(12) Pages: 1184-5
  • Peer Reviewed
• [Journal Article] Effects of surgical ventricular reconstruction and mitral complex reconstruction on cardiac oxidative metabolism and efficiency in nonischemic and ischemic dilated cardiomyopathy (2011)
  • Author(s): Sugiki T, Naya M, Manabe O, Wakasa S, Kubota S, Chiba S, Iwano H, Yamada S, Yoshinaga K, Tamaki N, Tsutsui H, Matsui Y
  • Journal Title: JACC Cardiovasc Imaging Volume: 4(7) Pages: 762-70
  • Peer Reviewed
• [Journal Article] Tsutsui H:Myocardial oxidative metabolism is increased due to haemodynamic overload in patients with aortic valve stenosis: assessment using11C-acetate positron emission tomography (2010)
  • Author(s): Naya M, Chiba S, Iwano H, Yamada S, Katoh C, Manabe O, Yoshinaga K, Matsui Y, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 37 Pages: 2242-2248
  • Peer Reviewed
• [Presentation] Heterogenous Reduction of Myocardial Oxidative Metabolism Correlates Reverse Remodeling after Cardiac Resynchronization Therapy in Patients with Heart Failure (2013)
  • Author(s): 千葉知
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2013-03-15
• [Presentation] Prone position acquisition of myocardial 123I metaiodobenzylguanidine (MIBG) SPECT shows closer regional uptake to 11C hydroxyephedrine PET (2012)
  • Author(s): Yoshinaga K
  • Organizer: 2012 SNM(Society of Nuclear Medicine) Annual Meeting
  • Place of Presentation: Miami Beach Convention Center (USA)
  • Year and Date: 20120609-13
• [Presentation] Prone体位撮像により123I MIBG SPECTの心筋局所集積は改善し11C hydroxyephedrinePETに近づく. (2012)
  • Author(s): 吉永恵一郎
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌(札幌)
  • Year and Date: 2012-10-12
• [Presentation] 重症左心不全に対する左室形成術後に左室拡張能改善と心筋酸素代謝軽減を認める (2012)
  • Author(s): 千葉知
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌(札幌)
  • Year and Date: 2012-10-12
• [Presentation] 重症左心不全患者に対する修正左室形成術(オーバーラッピング法)前後の左室拡張能と心筋酸素代謝の検討. (2012)
  • Author(s): 千葉知
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航金沢(金沢)
  • Year and Date: 2012-09-15
• [Presentation] 心筋症患者における遅延造影MRIと18F-FDGPETの比較 (2012)
  • Author(s): 真鍋治
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2012-04-14
• [Presentation] Improvement of Cardiac Efficiency and Diastolic Function after Surgical Ventricular Reconstruction in Patients with End-Stage Heart Failure (2012)
  • Author(s): 千葉知
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: マリンメッセ福岡(福岡)
  • Year and Date: 2012-03-17
• [Presentation] Enhanced Myocardial 18F-FDG Uptake in Patients with NonischemicCardiomyopathy in Comparison with Late Gadolinium Enhanced MRI. (2011)
  • Author(s): Manabe O
  • Organizer: Radiological Society of North America97th Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place (USA)
  • Year and Date: 20111127-1202
• [Presentation] Rubidium-82PETにおける局所心筋血流量の冠動脈疾患における診断的付加価値 (2011)
  • Author(s): 吉永恵一郎
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場・神戸ポートピアホテル(神戸)
  • Year and Date: 20110923-25
• [Presentation] Effects of Surgical Ventricular Reconstruction on Myocardial Oxidative Metabolism Assessed by C-11 Acetate PET in Patients with End-Stage Heart Failure (2011)
  • Author(s): 千葉知
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 20110803-04
• [Presentation] Characterization of myocardinal 123I metaiodobenzylguanidine(MIBG) distribution in comparison with 11C hydroxyephedrine PET in normal subject (2011)
  • Author(s): Yosinaga K
  • Organizer: 58th Society of Nuclear Medicine 2011Annual Meeting
  • Place of Presentation: SanAntonio Convention Center (USA)
  • Year and Date: 20110604-08
• [Presentation] Quantification of regional myocardial blood flow using 3D Rubidium-82 PET-Comparison with 2D Rubidium-82 data acquisition (2011)
  • Author(s): Yosinaga K
  • Organizer: 58th Society of Nuclear Medicine 2011Annual Meeting
  • Place of Presentation: SanAntonio Convention Center (USA)
  • Year and Date: 20110604-08
• [Presentation] Changes in myocardial oxidative metabolism after surgical ventricular reconstruction in patients with end stage heart failure depends on improvement in diastolic function (2011)
  • Author(s): Chiba S
  • Organizer: 58th Society of Nuclear Medicine 2011Annual Meeting
  • Place of Presentation: SanAntonio Convention Center (USA)
  • Year and Date: 20110604-08
• [Presentation] Accelerated Tc-99m sestamibi clearances associated with mitochondrial dysfunction and regionalLV dysfunction in perfused myocardium in acute coronary syndrome. (2011)
  • Author(s): Yoshinaga K
  • Organizer: 10th International Confefence ofNon-Invasive Cardiovascular Imaging
  • Place of Presentation: RAI Amsterdam(Netherlands)
  • Year and Date: 20110515-18
• [Presentation] 11C hydroxyephedrinePETとの比較による123Imetaiodobenzylguanidine (MIBG) SPECT の心筋局所集積の特徴 (2011)
  • Author(s): 吉永恵一郎
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場(筑波)
  • Year and Date: 2011-09-28
• [Presentation] ジェネレータ産生82RbPETを用いた2次元及び3次元収集による心筋血流量の定量およびその再現性について、また15H2OPETとの比較. (2010)
  • Author(s): 真鍋治
  • Organizer: 第20回日本心臓核医学会総会・学術大会
  • Place of Presentation: 東京コンファレンスセンター品川(東京都)
  • Year and Date: 20100625-26
• [Presentation] Quantification of myocardial blood flow with Rubidium-823D-data acquisition - Comparison withO-15 labeled water dynamic PET. (2010)
  • Author(s): Manabe O
  • Organizer: The 57th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Salt Palace Convention Center (USA)
  • Year and Date: 20100605-09
• [Presentation] Repeatability of myocardial blood flow measurements with 3D data acquisition using Rubidium-82 PET (2010)
  • Author(s): Manabe O
  • Organizer: The 57th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Salt Palace Convention Center (USA)
  • Year and Date: 20100605-09
• [Presentation] 左心不全患者に対する左室形成術前後の心筋酸素代謝の検討:左室形成術を行うと術前に亢進していた心筋酸素代謝が軽減する (2010)
  • Author(s): 千葉知
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2010-09-19