2012 Fiscal Year Final Research Report
Early prediction of therapeutic effect of molecular targeting therapy for solid malignant tumor with imaging biomarkers
| Project/Area Number |
22591319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肝細胞癌 / 分子標的治療 / 造影CT / Dual-Energy CT / ヨードマップ |
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| Research Abstract |
Dilatation of intratumoral vessels on multiphasic contrast enhanced CT was estimated to be one of the key findings for prediction of early therapeutic effect evaluation of molecular-targeting therapy for hepatocellular carcinoma (HCC). There are no significant correlation between hemodynamic parameters of CT perfusion just after starting of molecular-targeting therapy for HCC and long term therapeutic effect of it. In contrast, intratumoral iodine measurement obtained by dual-energy CT technique might be used as surrogate marker for early prediction of therapeutic effect of molecular targeting therapy for HCC.
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Research Products
(16 results)
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[Journal Article] 薬物トランスポーターからみたGd-EOB-DTPA 造影MRI2011
Author(s)
小林 聡, 北尾 梓, 松井 修, 蒲田敏文, 眞田順一郎, 香田 渉, 南 哲弥, 龍 泰治, 川井恵一, 新村理絵子, 小坂一斗, 中村功一, 米田憲秀
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Journal Title
臨床画像
Volume: 27
Pages: 302-309
URL
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[Journal Article] d-EOB-DTPA造影MRIによる肝腫瘍画像診断2010
Author(s)
小林 聡, 松井 修, 蒲田敏文, 眞田順一郎, 香田 渉, 南 哲弥, 龍 泰治, 川井恵一,新村理絵子, 小坂一斗, 米田憲秀, 杉盛夏樹, 五十嵐紗耶, 松原崇史
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Journal Title
Rad Fa
Volume: 8
Pages: 78-80
URL
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