2012 Fiscal Year Final Research Report
Development of New PET Imaging for Prostate Cancer using EstrogenReceptor Ligand
| Project/Area Number |
22591323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OOYAMA Nobuyuki 福井大学, 医学部附属病院, 講師 (20223977)
MORI Tetsuya 福井大学, 高エネルギー医学研究センター, 助教 (40397287)
KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
TAKAHARA Noriko 福井大学, 医学部附属病院, 医員 (50572426)
YOKOYAMA Osamu 福井大学, 医学部, 教授 (90242552)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 核医学(PET を含む) |
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| Research Abstract |
The expression and role of estrogen receptor (ER) in prostate cancer receiving androgen ablation therapy remains unclear. We assessed the expression of ER by using 16α-[18F]fluoro-17β-estradiol (FES) in prostate cancer following androgen ablation therapy in vitro and in vivo. The results of the studies indicate that ERαexpression increased under androgen ablation in vitro and in vivo, showing the role of ERα in the acquaintance of androgen independency of prostate cancer. FES is a promising tracer in monitoring the expression of ERα in prostate cancer following androgen ablation therapy.
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