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2012 Fiscal Year Final Research Report

Development of New PET Imaging for Prostate Cancer using EstrogenReceptor Ligand

Research Project

  • PDF
Project/Area Number 22591323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of Fukui

Principal Investigator

ISHIDA Hirokazu  福井大学, 医学部附属病院, 助教 (00293431)

Co-Investigator(Kenkyū-buntansha) OOYAMA Nobuyuki  福井大学, 医学部附属病院, 講師 (20223977)
MORI Tetsuya  福井大学, 高エネルギー医学研究センター, 助教 (40397287)
KIYONO Yasushi  福井大学, 高エネルギー医学研究センター, 教授 (50305603)
TAKAHARA Noriko  福井大学, 医学部附属病院, 医員 (50572426)
YOKOYAMA Osamu  福井大学, 医学部, 教授 (90242552)
Project Period (FY) 2010 – 2012
Keywords核医学(PET を含む)
Research Abstract

The expression and role of estrogen receptor (ER) in prostate cancer receiving androgen ablation therapy remains unclear. We assessed the expression of ER by using 16α-[18F]fluoro-17β-estradiol (FES) in prostate cancer following androgen ablation therapy in vitro and in vivo. The results of the studies indicate that ERαexpression increased under androgen ablation in vitro and in vivo, showing the role of ERα in the acquaintance of androgen independency of prostate cancer. FES is a promising tracer in monitoring the expression of ERα in prostate cancer following androgen ablation therapy.

  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Monoclonal antibody RM2 as a potential ligand for a new immunotracer for prostate cancer imaging2012

    • Author(s)
      Y. Hasegawa, N. Oyama, K. Nagase, Y. Fujibayashi, T. Furukawa, Y. Murayama, Y. Arai, S. Saito, M.J. Welch, O. Yokoyama
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 39 Pages: 944-947

    • Peer Reviewed
  • [Journal Article] Early response assessment in prostate carcinoma by 18F-fluorothymidine following anticancer therapy with docetaxel using preclinical tumour models2011

    • Author(s)
      N. Oyama, Y. Hasegawa, Y. Kiyono, M. Kobayashi, Y. Fujibayashi, D.E. Ponde, C. Dence, M.J. Welch, O. Yokoyama
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 38 Pages: 81-89

    • Peer Reviewed
  • [Journal Article] 前立腺癌の診断 画像診断 PET、 PET-CT2011

    • Author(s)
      大山 伸幸, 横山 修
    • Journal Title

      日本臨床

      Volume: 69 Pages: 280-284

    • Peer Reviewed
  • [Presentation] PETトレーサーFESを用いたアンドロゲン除去療法がおよぼす前立腺癌細胞におけるEstrogen受容体発現の変化に関する基礎的検討2013

    • Author(s)
      長谷川陽子、大山伸幸、高原典子、三輪吉司、秋野裕信、森 哲也、清野 泰、横山 修
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2013-04-25
  • [Presentation] In vitro and in vivo assessment of 16α-[18F]fluoro- 17β- estradiol as a new PET tracer for evaluating ER expression of prostate cancer following androgen ablation therapy2012

    • Author(s)
      N. Oyama, Y. Hasegawa, N. Takahara, Y. Miwa, H. Akino, T. Mori, Y. Kiyono, O. Yokoyama
    • Organizer
      15th ICHSHC (International Congress on Hormonal Steroids and Hormones & Cancer)
    • Place of Presentation
      金沢
    • Year and Date
      2012-11-17
  • [Presentation] FES を用いたアンドロゲン除去療法が及ぼす前立腺癌のエストロゲン受容体発現の変化に関する基礎的検討2012

    • Author(s)
      大山伸幸, 長谷川陽子, 高原典子, 森 哲也, 清野 泰
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-10-11
  • [Presentation] In vivo assessment of 16α- [18F]fluoro-17β-estradiol as a new PET tracer for evaluating ER expression of prostate cancer following androgen ablation therapy2012

    • Author(s)
      Y. Hasegawa , N. Oyama, N. Takahara, Y. Miwa , H. Akino, T. Mori, Y. Kiyono, O. Yokoyama
    • Organizer
      32nd Congress of the Societe Internationale d'Urologie
    • Place of Presentation
      福岡
    • Year and Date
      2012-09-30
  • [Presentation] 新規 PET トレーサーFES を用いたアンドロゲン除去療法がおよぼす前立腺癌細胞におけるEstrogen 受容体発現の変化に関する基礎的検討2012

    • Author(s)
      長谷川陽子、 大山伸幸、 高原典子、 森 哲也、岡沢秀彦、横山 修
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-22
  • [Remarks]

    • URL

      http://www.med.u-fukui.ac.jp/home/ufms/file/kenkyu/welcome.html

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Published: 2014-08-29   Modified: 2022-10-25  

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