Developing a low-radiation-dose high-image-quality intelligent contrast-enhanced CT system in the era of multidetector-row CT

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591324
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gifu University
• Principal Investigator: KANEMATSU Masayuki 岐阜大学, 医学部付属病院, 准教授 (40252134)
• Co-Investigator(Kenkyū-buntansha): KONDO Hiroshi 岐阜大学, 医学部付属病院, 講師 (20324311) ; GOSHIMA Satoshi 岐阜大学, 医学部付属病院, 助教 (90402205) ; WATANABE Haruo 岐阜大学, 医学研究科, 非常勤講師 (30456529)
• Project Period (FY): 2010 – 2012
• Keywords: CT / インテリジェント CT / ボーラストラッキング / 低被ばく

Research Abstract

The radiation exposure per a citizen in our country leads to approximately 3.7 times of the world average. Reduction of radiation exposure in CT is urgent issue, and the usefulness of low tube voltage CT has been reported. However, the reduction of radiation dose often leads to image quality deterioration by increased image noise and the contrast decrease, and the noise reduction filter has been developed for the compensation. On the other hand, side effects such as anaphylaxis or renal dysfunction related to iodine administration, but there is not evident relation between the iodine amount of 500 mg/kg - around 750 mg/kg and such adverse events. We have conducted upper abdominal CT examinations with the iodine load of 600 mg/kg, but it is believed that the dose of 521 mg/kg is sufficient for the contrast enhancement. Based on such backgrounds,we attempted to develop bolus-tracking techniques for multiple- contrast phase using two CT s in ourhospital. I also developed a program to enable the imaging at the contrast enhancement peak of organs while setting ROIs to the aorta, pancreas, and liver parenchyma. Based on the research data,we optimized the CT examinations adjusting with body habitus of patients, decreasing radiation dose, optimizing the most effective contrast phase. We also attempted to connect the system to theintelligent contrast injector. We present these results at Radiological Society of North America in2012.

Research Products

• [Journal Article] Enhancement of anatomical structures and detection of metastatic cervical lymph nodes: comparison of two different contrast material doses (2012)
  • Author(s): Watanabe H, Kanematsu M, Kato H, Kojima T, Miyoshi T, Goshima S,Kondo H, Kawada H, Noda Y, Moriyama N
  • Journal Title: Jpn J Radiol
  • Peer Reviewed
• [Journal Article] Automatic localization of solid organs on 3D CT images by a collaborative majority voting decision based on ensemble learning (2012)
  • Author(s): Zhou X, Wang S, Chen H, Hara T, Yokoyama R, Kanematsu M, Fujita H
  • Journal Title: Comput Med Imaging Graph Volume: 36(4) Pages: 304-13
  • Peer Reviewed
• [Journal Article] Automated segmentation of recuts abdominis muscle using shape model in X-ray CT images (2011)
  • Author(s): Kamiya N, Zhou X, Chen H, Muramatsu C, Hara T, Yokoyama R,Kanematsu M, Hoshi H, Fujita H
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2011 Pages: 7993-6
  • Peer Reviewed
• [Journal Article] Will CT take second billing to MR imaging for the diagnosis of hypervascular hepatocellular carcinomas hereafter (2011)
  • Author(s): Kanematsu M.
  • Journal Title: Radiology Volume: 260(2) Pages: 607
  • Peer Reviewed
• [Journal Article] Automated segmentation of psoas major muscle in X-ray CT images by use of a shape model: preliminary study (2011)
  • Author(s): Kamiya N, Zhou X, Chen H, Muramatsu C, Hara T, Yokoyama R, Kanematsu M, Hoshi H, Fujita H
  • Journal Title: Radiol Phys Technol
  • Peer Reviewed
• [Journal Article] CT of the pancreas: comparison of anatomic structure depiction, image quality, and radiation exposure between 320-detector volumetric images and 64-detector helical images (2011)
  • Author(s): Goshima S, Kanematsu M, Nishibori H, Sakurai K, Miyazawa D, Watanabe H, Kondo H, Shiratori Y, Onozuka M, Moriyama N, Bae KT
  • Journal Title: Radiology Volume: 260(1) Pages: 139-47
  • Peer Reviewed
• [Journal Article] Aortic and hepatic enhancement at multidetector CT: Evaluation of optimal iodine dose determined by lean body weight (2010)
  • Author(s): Kondo H, Kanematsu M, Goshima S, Watanabe H, Onozuka M, Moriyama N, Bae KT
  • Journal Title: Eur J Radiol
  • Peer Reviewed
• [Journal Article] Improvement of image quality of low radiation dose abdominal CT by increasing contrast enhancement (2010)
  • Author(s): Watanabe H, Kanematsu M, Miyoshi T, Goshima S, Kondo H, Moriyama N, Bae KT
  • Journal Title: AJR Am J Roentgenol. Volume: 195(4) Pages: 986-92
  • Peer Reviewed
• [Journal Article] Abdominal vascular and visceral parenchymal contrast enhancement in MDCT: Effects of injection duration. (2010)
  • Author(s): Tsuge Y, Kanematsu M, Goshima S, Kondo H, Yokoyama R, Miyoshi T,Onozuka M, Moriyama N, Bae KT
  • Journal Title: Eur J Radiol.
  • Peer Reviewed
• [Journal Article] Analysis of bone mineral density distribution at trabecular bones in thoracic and lumbar vertebrae using X-ray CT images (2010)
  • Author(s): Hayashi T, Chen H, Miyamoto K, Zhou X, Hara T, Yokoyama R, Kanematsu M, Hoshi H, Fujita H
  • Journal Title: J Bone Miner Metab
  • Peer Reviewed
• [Journal Article] Body Size Indexes for Optimizing Iodine Dose for Aortic and Hepatic Enhancement at Multidetector CT: Comparison of Total Body Weight (2010)
  • Author(s): Kondo H, Kanematsu M, Goshima S,Tomita Y, Kim MJ, Moriyama N, Onozuka M, Shiratori Y, Bae KT.
  • Journal Title: Lean Body Weight, and Blood Volume. Radiology Volume: 254 Pages: 163-169
  • Peer Reviewed
• [Presentation] Preoperative Planning for Endovascular Aortic Repair of Abdominal Aortic Aneurysms: Feasibility Study of Non-contrast MR Imaging vs Contrast-enhanced CT (2012)
  • Author(s): Goshima S, Noda S, Sakurai K, Kawada H, Kondo H, Watanabe H, Kanematsu M, Bae KT
  • Organizer: 第98回北米放射線学会, シカゴ
  • Place of Presentation: USA
  • Year and Date: 2012-12-25
• [Presentation] Automated Organ Segmentation on CT Images by Using Similar Image Retrieval Based on Machine-Learning. (2012)
  • Author(s): Watanabe A, Zhou X, Hara T, Yokoyama R, Kanematsu M, Fujita H.
  • Organizer: 第98回北米放射線学会, シカゴ
  • Place of Presentation: USA
  • Year and Date: 2012-12-25
• [Presentation] Fully Automated Quantitative Measurement of Multiple Skeletal Muscles in Torso CT Images by Use of a Statistical Shape Models. (2012)
  • Author(s): Kamiya N, Zhou X, Kondo J, Muramatsu C, Hara T, Fujita H, Chen H, Yokoyama R, Kanematsu M, Hoshi H
  • Organizer: 第98回北米放射線学会, シカゴ
  • Place of Presentation: USA
  • Year and Date: 2012-12-25
• [Presentation] 腹部造影 CT-最適検査の標準化に向けての今後の視点- (2012)
  • Author(s): 兼松雅之
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-12
• [Presentation] Image Quality and Radiation in CT of the Pancreas: Comparison of 320-MDCT with and without Adaptive Iterative Dose Reduction and 64-MDCT (2011)
  • Author(s): Goshima S, Tsuge Y, Miyazawa D, Nishibori H, Watanabe H, Yoshida M, Kawada H, Kondo H, Kanematsu M, Bae KT
  • Organizer: 第97回北米放射線学会, シカゴ
  • Place of Presentation: USA
  • Year and Date: 2011-12-25
• [Presentation] Goshima S, Kondo H, Watanabe H, Kawada H, Mehta D, Kanematsu M, Bae KT (2011)
  • Author(s): Goshima S, Kondo H, Watanabe H, Kawada H, Mehta D, Kanematsu M, Bae KT
  • Organizer: 第97回北米放射線学会, シカゴ
  • Place of Presentation: USA
  • Year and Date: 2011-12-25
• [Presentation] Hypervascular Hepatic Nodules Mimicking Hepatocellular Carcinoma in Noncirrhotic and Cirrhotic Liver: Findings at CT, MR imaging, Pathologic, and Clinical Correlation (2011)
  • Author(s): Haruo Watanabe, Satoshi Goshima, Hiroshi Kondo, Hiroshi Kawada, Yoshihumi Noda, Masayuki Kanematsu
  • Organizer: 第97回北米放射線学会,シカゴ
  • Place of Presentation: USA
  • Year and Date: 2011-12-25
• [Presentation] Automatic Organ Localization in X-ray Torso CT Images Using Machine-learning Approach. (2011)
  • Author(s): Xiangrong Zhou, Takeshi Hara , Huayue Chen, Ryujiro Yokoyama, Masayuki Kanematsu , Hiroshi Fujita
  • Organizer: 第97回北米放射線学会,シカゴ
  • Place of Presentation: USA
  • Year and Date: 2011-12-25
• [Presentation] Quantitative Staging the Hepatic Fibrosis: Computer-aided Diagnosis by Shape, Texture, Volume, and Elasticity Analysis (2011)
  • Author(s): Xuejun Zhang, Satoshi Goshima, X. Zhou, Takeshi. Hara , Masayuki Kanematsu, Hiroshi Fujita
  • Organizer: 第97回北米放射線学会,シカゴ
  • Place of Presentation: USA
  • Year and Date: 2011-12-25
• [Presentation] 腹部造影 CT -最適検査の標準化に向けての今後の視点- (2011)
  • Author(s): 兼松雅之
  • Organizer: 第39回日本放射線技術学会秋期学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2011-10-28
• [Presentation] 腹部造影 CT-最適検査の標準化に向けての今後の視点- (2011)
  • Author(s): 兼松雅之
  • Organizer: 第47回日本医学放射線学会秋期臨床大会
  • Place of Presentation: 下関
  • Year and Date: 2011-10-21
• [Presentation] Uterine Arterial Embolization for Postpartum Hemorrhage: Clinical Indications, Radiologic Findings, and Treatment Efficacies. (2010)
  • Author(s): Hiroshi Kawada, Satoshi Goshima, Masayuki Kanematsu, Hiroshi Kondo, Haruo Watanabe, Kyongtae Tyler Bae.
  • Organizer: 第96回北米放射線学会,シカゴ
  • Place of Presentation: USA
  • Year and Date: 2010-11-29