2013 Fiscal Year Final Research Report
An establishment of the novel molecular imaging technique for the quantitative evaluation of the intra-tumoral apoptosis
| Project/Area Number |
22591335
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | アポトーシス / MRI / 分子イメージング / ADC / 拡散強調画像 |
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| Research Abstract |
The novel molecular imaging technique has been established deductively for quantitative evaluation of apoptosis using newly developed bio-phantom, which enables cellular imaging with clinical imaging devices under three-dimensional cell-culture cellular culture.
The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis.
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Research Products
(10 results)
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[Journal Article] In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Jurkat Cells Using Bio-phantoms2013
Author(s)
Kazunori Katashima, Masahiro Kuroda, Masakazu Ashida, Takanori Sasaki, Takehito Taguchi, Hidenobu Matsuzaki, Jun Murakami, Yoshinobu Yanagi, Miki Hisatomi, Marina Hara, Hirokazu Kato, Yuichi Ohmura, Tomoki Kobayashi, Susumu Kanazawa, Sosuke Harada, Mitsuhiro Takemoto, Seiichiro Ohno, Seiichi Mimura, and Junichi Asaumi
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Journal Title
Acta Med Okayama
Volume: 67巻
Pages: 359-367
Peer Reviewed
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