2012 Fiscal Year Final Research Report
Intratumoral heterogeneity in brain tumor using PET molecular imaging
| Project/Area Number |
22591337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuka 香川大学, 医学部附属病院, 講師 (30335872)
KAWAI Nobuyuki 香川大学, 医学部, 准教授 (40294756)
KUDOMI Nobuyuki 香川大学, 医学部, 准教授 (20552045)
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| Co-Investigator(Renkei-kenkyūsha) |
AGA Fumitoshi 香川大学, 医学部附属病院, 病院助教 (30596078)
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| Project Period (FY) |
2010 – 2012
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| Keywords | PET 検査 / F-18 FDG / C-11 methionine / 分子イメージング / 不均一性 / 脳腫瘍 |
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| Research Abstract |
Heterogeneity is a recognized characteristic of malignant tumor. It has been reported to be associated with factors that influence resistance to therapy such as histological features including cellular proliferation, necrosis, and physiological features including degree of vascularity, gene expression, energy metabolism, and oxygenation. All these aspects of intratumoral heterogeneity may affect the biological behavior of tumors in patients, which may manifest as variability in prognosis and treatment response. The purpose of this study was to quantitatively measure intratumoral heterogeneity, and to delineate the differences in the distribution of F-18 FDG, F-18 FLT, and C-11 methionine in patients with primary brain tumors.
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