White matter changes in idiopathic normal pressure hydrocephalus evaluated by diffusion MRI including diffusion tensor and QSI

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591352
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Juntendo University
• Principal Investigator: AOKI Shigeki 順天堂大学, 医学部, 教授 (80222470)
• Co-Investigator(Kenkyū-buntansha): MIZUSAWA Hidehiro 東京医科歯科大学, 医学部, 教授 (30144091)
• Co-Investigator(Renkei-kenkyūsha): YUASA Tatsuhiko 鎌ヶ谷総合病院, 部長 (10115090)
• Project Period (FY): 2010 – 2012
• Keywords: 正常圧水頭症 / MRI / DTI / 拡散テンソル / diffusion / diffusional kurtosis / Q space imaging / biomarker

Research Abstract

Since histological evaluation of iNPH is difficult, we explored the white matter changes of idiopathic normal pressure hydrocephalus (iNPH) using diffusion analysis of MRI (dMRI). White matter changes related to cognitive decline were observed using diffusion tensor imaging (DTI). The corticospinal tract of iNPH showed diffusional changes due to compression without significant axonal deterioration using DTI. Advanced diffusional MRI (QSI,DKI) showed increased non-Gaussianity consistent with DTI findings. Diffusional MRI might become a unique biomarker of iNPH.

Research Products

• [Journal Article] Relationship between cognitive impairment and white-matter alteration in Parkinson's disease with dementia: tract-based spatial statistics and tract-specific analysis (2013)
  • Author(s): Kamagata K, Motoi Y, Tomiyama H, Abe O, Ito K, Shimoji K, Suzuki M, Hori M, Nakanishi A, Sano T, Kuwatsuru R, Sasai K, Aoki S,Hattori N.
  • Journal Title: Eur Radiol
• [Journal Article] Effects of diffusional kurtosis imaging parameters on diffusion quantification (2013)
  • Author(s): Fukunaga I, Hori M, Masutani Y, Hamasaki N, Sato S, Suzuki Y, Kumagai F, Kosuge M, Hoshito H, Kamagata K, Shimoji K, Nakanishi A, Aoki S,Senoo A
  • Journal Title: Radiol Phys Technol
• [Journal Article] Visualizing non-Gaussian diffusion: clinical application of q-space imaging and diffusional kurtosis imaging of the brain and spine (2012)
  • Author(s): Hori M, Fukunaga I, Masutani Y, Taoka T, Kamagata K, Suzuki Y, Aoki S.
  • Journal Title: Magnetic resonance in medical sciences Volume: 11(4) Pages: 221-33
• [Journal Article] White matter alteration of the cingulum in Parkinson disease with and without dementia: evaluation by diffusion tensor tract-specific analysis (2012)
  • Author(s): Kamagata K, Motoi Y, Abe O, Shimoji K, Hori M, Nakanishi A, Sano T, Kuwatsuru R, Aoki S,Hattori N
  • Journal Title: AJNR Volume: 33(5) Pages: 890-5
• [Journal Article] Different patterns of fornix damage in idiopathic normal pressure hydrocephalus and Alzheimer disease (2012)
  • Author(s): Hattori T, Sato R, Aoki S, Yuasa T, Mizusawa H
  • Journal Title: AJNR Volume: 33(2) Pages: 274-9
• [Journal Article] Cognitive status correlates with white matter alteration in Parkinson's disease (2012)
  • Author(s): Hattori T, Orimo S, Aoki S, Ito K, Abe O, Amano A, Sato R, Sakai K, Mizusawa H
  • Journal Title: Human brain mapping Volume: 33(3) Pages: 727-39
• [Journal Article] White matter alteration in idiopathic normal pressure hydro- cephalus: tract-based spatial statistics study (2012)
  • Author(s): Hattori T, Ito K, Aoki S, Yuasa T, Sato R, Ishikawa M, Sawaura H, Hori M, Mizusawa H
  • Journal Title: AJNR Volume: 33(1) Pages: 97-103
• [Journal Article] Altered Microstructure in Corticospinal Tract in Idiopathic Normal Pressure Hydrocephalus: Comparison with Alzheimer Disease and Parkinson Disease with Dementia (2011)
  • Author(s): Hattori T, Yuasa T, Aoki S, Sato R, Sawaura H, Mori T, Mizusawa H
  • Journal Title: American Journal of Neuroradiology Volume: 32(9) Pages: 1681-7