2012 Fiscal Year Final Research Report
Radiotoxicity after Sr-89 therapy for bone metastasis using γ-H2AX Foci of DNA damage in lymphocytes
| Project/Area Number |
22591355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
DOAI Mariko 金沢医科大学, 医学部, 助教 (40515673)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Naoto 金沢医科大学, 医学部, 教授 (40210926)
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| Co-Investigator(Renkei-kenkyūsha) |
IWABUCHI Kuniyoshi 金沢医科大学, 医学部, 教授 (10232696)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ストロンチウム / 放射線組織障害 / リンパ球 / γ-H2AX |
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| Research Abstract |
The purpose of our study was to evaluate the degree of radiotoxicity to lymphocytes after strontium-89 therapy for bone metastases using γ-H2AX foci immunodetection. DNA damage to lymphocytes induced by Sr-89 in vivo should result in increased numbers of cells with nuclear foci stained by γ-H2AX. γ-H2AX foci immunodetection in lymphocytes may detect radiation-induced DNA damage associated with strontium-89 therapy for bone metastases, and may facilitate estimation of the radiation doses absorbed with thistherapy.
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