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2012 Fiscal Year Final Research Report

Early detection of radiation induced apoptosis by 99mTc-Annexin V andFDG in a lung cancer cell line.

Research Project

  • PDF
Project/Area Number 22591357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKansai Medical University

Principal Investigator

KAWA Soukichi  関西医科大学, 医学部, 准教授 (30152896)

Co-Investigator(Kenkyū-buntansha) UENO Yasuhiro  関西医科大学, 医学部, 助教 (10425069)
Project Period (FY) 2010 – 2012
Keywordsアネキシン V / 放射線誘発 / TUNEL 法 / アポトーシス
Research Abstract

^99mTc-HYNIC-coupled Annexin V accumulation with 9 Gy and 12 Gy, doses was found to be higher than in the control and 3-6 Gy irradiated groups at 48 hours post irradiation. Annexin V may prove to be an effective radiotracer for early assessment of radiation therapy efficacy, via apoptosis, in human lung cancers.

  • Research Products

    (4 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] An investigation of the early detection of radiation induced apoptosis by 99m Tc-Annexin V and 201 Thallium-Chloride in a lung cancer cell line.2012

    • Author(s)
      Khoda Me, Utsunomiya K, Ha-Kawa S, Kanno S,Kono Y, Sawada S.
    • Journal Title

      J Radiat Res

      Volume: 53 Pages: 361-367

    • DOI

      DOI:10.1269/jrr.11177

    • Peer Reviewed
  • [Presentation] Time dependent longitudinal effects of radiation-induced suppression of multidrug resistance and cell proliferation potency in a non-small lung cancer cell line.2012

    • Author(s)
      Y. Kono, K. Utsunomiya, S. Kanno, Y. Ueno, S.Ha-Kawa, N. Tanigawa
    • Organizer
      European Association of Nuclear Medicine
    • Place of Presentation
      Milan, Italy
    • Year and Date
      20121027-31
  • [Presentation] 放射線の肺癌細胞におけるMDRと細胞増殖能への影響について2012

    • Author(s)
      河野由美子、宇都宮啓太、菅野渉平、上埜泰寛、河相吉、谷川昇
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌市
    • Year and Date
      20121011-20121011
  • [Presentation] 放射線照射によるMDR抑制効果と細胞増殖能における経時的変化の検討2012

    • Author(s)
      河野由美子、宇都宮啓太、菅野渉平、上埜泰寛、河相吉、澤田敏
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      20120412-15

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Published: 2014-08-29  

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