The Effect of intra-vertebral injection of Bisphosphonate: An Experimental Study in an Osteoporotic Rabbit Lumbar Spine Model following Radiofrequency Ablation

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591367
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: NAKATSUKA Atsuhiro 三重大学, 医学部附属病院, 助教 (70303740)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Kan 三重大学, 医学部附属病院, 病院長 (70106988) ; YAMAKADO Koichiro 三重大学, 医学部附属病院, 准教授 (20263022)
• Project Period (FY): 2010 – 2012
• Keywords: ラジオ波焼灼術・ / 椎体形成術 / 骨粗鬆症 / マイクロCT・ビスフォスフォネート

Research Abstract

Bone strength in ablated lumbar spines was significantly fragile as compared with control group due to bony microarchitectural destruction of the trabeculae. Both effects of intra-venous and intra-vertebral injection of Bisphosphonate were found to be similar in changing in both bone strength and bony micro-architecture.

Research Products

• [Journal Article] Changes in Bone Structure and Strength following Radiofrequency Ablation with and without Vertebroplasty (2013)
  • Author(s): Atsuhiro Nakatsuka, Koichiro Yamakado
  • Journal Title: an ex vivo Study in Swine Spine Journal of Biomedical Science and Engineering
  • Peer Reviewed
• [Journal Article] 増骨剤の治療効果に関する生体力学的評価 (2011)
  • Author(s): 上田 怜, 中塚豊真, 稲葉忠司
  • Journal Title: 三重大学工学部修士論文集
• [Presentation] 兎の腰椎におけるRFA後のビスホスホネートの効果に関する実験的検討 (2013)
  • Author(s): 中塚豊真、山門亨一郎
  • Organizer: 本INTERVENTIONAL RADIOLOGY学会第32回中部・第31回関西合同地方会
  • Place of Presentation: 大阪府、大阪市北区堂島、ホテルエルセラーン大阪
  • Year and Date: 2013-02-18
• [Presentation] Effect of Intra-venous Versus Intra-vertebral Injection of Bisphosphonate in an Rabbit Lumbar Spine Model weakened by Radiofrequency Ablation: Changes in Physical Properties and Micro CT-Histopathologic Correlation (2011)
  • Author(s): Atsuhiro Nakatsuka, Koichiro Yamakado, Kan Takeda
  • Organizer: 第97回北米放射線科学会(97th Annual Meeting
  • Place of Presentation: 米国、シカゴ、マコーミックプライス・コンベンションセンター
  • Year and Date: 2011-12-02
• [Presentation] Osteoporotic Rabbit Lumbar Spine Model following Radiofrequency Ablation; Evaluation of Physical Properties and Micro CTHistopathologicCorrelation (2011)
  • Author(s): Atsuhiro Nakatsuka, Koichiro Yamakado, Ray Ueda, Kan Takeda
  • Organizer: 2011 Society of Interventional Radiology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-03-30