Radio-enhancement effects by Parthenolide, NF-κB inhibitor, and analysis of these molecular mechanism.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: HAYASHI Sachiko 福井大学, 医学部, 助教 (00218570)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Hideki 福井大学, 高エネルギー研究センター, 准教授 (40142377)
• Project Period (FY): 2010 – 2012
• Keywords: NF-κB 阻害剤 / パルテノライド / Apoptosis / ras/raf/MAPK / DU145 細胞

Research Abstract

PTL showed significant radio- and thermo-sensitization in human prostate cancer cells. It was suggested that lethal damage of cells was due to the induction of apoptosis or G2M cell cycle arrest via the 3 cascades to Ras/Raf/MAPK signaling upstream of NF-κB.

Research Products

• [Journal Article] Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer androgen-independent cell lines (2011)
  • Author(s): HAYASHI SACHIKO, KOSHIBA KEN, HATASHITA MASANORI, SATO TAKEFUMI, JUJO YUTAKA, SUZUKI RYUTA, TANAKA YUKIE and SHIOURA HIROKI
  • Journal Title: International Journal ofMolecular Medicine Volume: 28 Pages: 1033-1042
  • Peer Reviewed
• [Journal Article] Inhibition of NF-κB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell-cycle arrest in human lung adenocarcinoma cells (2010)
  • Author(s): HAYASHI SACHIKO, SAKURAI HIROAKI, HAYASHI AKIO, TANAKA YUKIE, HATASHITA MASANORI and SHIOURA HIROKI
  • Journal Title: International Journal ofMolecular Medicine Volume: 25 Pages: 81-87
  • Peer Reviewed
• [Presentation] Thermosensitization by parthenolide, a NF-κB inhibitor, and apoptosis induction or cell-cycle arrest via the MAPK cascade (2012)
  • Author(s): Hayashi Sachiko, Hatashita Masanori, Koshiba Ken, Sato Takefumi, Jujo Yutaka, Suzuki Ryuta, Shiozaki Hisaya
  • Organizer: 17th World Congress on Advances in Oncology & 15th International Symposium on Molecular Medicine
  • Place of Presentation: Crete, Greece
  • Year and Date: 2012-10-12
• [Presentation] Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer cell lines (2012)
  • Author(s): HAYASHI Sachiko, KOSHIBA Ken, SHIOZAKI Hisaya, HATASHITA Masanori, SATO Takefumi, JUJO Yutaka, SUZUKI Ryuta
  • Organizer: 11th International Conference on Hyperthermic Oncology & 第29回日本ハイパーサーミア学会
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-30
• [Presentation] ヒト前立腺癌細胞における NF-κB 阻害剤パルテノライドの温熱増感効果と MAPK cascade 経由 apoptosis 誘導及び cellcycle arrest (2011)
  • Author(s): 林 幸子、畑下昌範、田中幸枝
  • Organizer: 第54回日本放射線影響学会
  • Place of Presentation: 神戸
  • Year and Date: 2011-11-18
• [Presentation] ヒト前立腺癌細胞におけるパルテノライドによる温熱増感効果と apoptosis 誘導及び cell-cycle arrest (2011)
  • Author(s): 林 幸子、畑下昌範、塩浦宏樹
  • Organizer: 第28回日本ハイパーサーミア学会
  • Place of Presentation: 愛知
  • Year and Date: 2011-09-09
• [Presentation] Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction (2011)
  • Author(s): HAYASHI SACHIKO, HATASHITA MASANORI, SHIOURA HIROKI, TANAKA YUKIE
  • Organizer: 14th International Congress Radiation Research, Poland
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2011-08-29
• [Presentation] ヒト前立腺癌細胞におけるパルテノライドの温熱増感効果と apoptosis 誘導及びcell-cycle arrest (2011)
  • Author(s): 林 幸子、畑下昌範、塩浦宏樹
  • Organizer: 第13回関西ハイパーサーミア研究会
  • Place of Presentation: 長岡京市
  • Year and Date: 2011-07-02
• [Presentation] アンドロゲン非依存性前立腺癌細胞におけるNF-κB 阻害剤 Parthenolide の温熱増感効果及び MAPK カスケードへの影響 (2010)
  • Author(s): 林 幸子、畑下昌範、塩浦宏樹
  • Organizer: 第53回日本放射線影響学会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-21