2012 Fiscal Year Final Research Report
Development of the next generation radiation therapy based on molecular imaging
| Project/Area Number |
22591392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TACHIBANA Izumi 近畿大学, 医学部附属病院, 助教 (80351633)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSONO Makoto 近畿大学, 医学部附属病院, 教授 (00281303)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 放射線治療 / 生物学 / 腫瘍 / 低酸素 / PET |
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| Research Abstract |
To visualize intratumoral hypoxic areas and their reoxygenation before and during fractionated radiation therapy (RT), 18F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) were performed. Ten patients, consisting of four head and neck cancers, four gastrointestinal cancers, one lung cancer, and one uterine cancer, were included. F-MISO PET/CT was performed twice before RT and during fractionated RT of approximately 20 Gy/10 fractions for eight of the 10 patients. F-MISO maximum standardized uptake values (SUVmax) of normal muscles and tumors were measured. The tumor-to-muscle (T/M) ratios of F-MISO SUVmax were also calculated. Mean SUVmax ± standard deviation (SD) of normal muscles was 1.25 ± 0.17, and SUVmax above the mean + 2 SD (≧1.60 SUV) was regarded as a hypoxic area. Nine of the 10 tumors had an F-MISO SUVmax of equal to or more than 1.60. All eight tumors examined twice showed a decrease in SUVmax, T/M ratio, or percentage of hypoxic volume (F-MISO ≧1.60) at approximately 20 Gy, indicating reoxygenation. In conclusion, accumulation of F-MISO of ≧1.60 SUV was regarded as an intratumoral hypoxic area in our F-MISO PET/CT system. Most human tumors (90%) in this small series had hypoxic areas before RT, although hypoxic volume was minimal (0.0-0.3%) for four of the 10 tumors. In addition, reoxygenation was observed in most tumors at two weeks of the fractionated RT.
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Research Products
(20 results)
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[Journal Article] Long-term follow-up of a randomized phase II study of cisplatin/ 5-FU concurrent chemoradiotherapy for esophageal cancer (KROSG0101/JROSG021)2012
Author(s)
Nishimura Y, Hiraoka M, Koike R, Nakamatsu K, Itasaka S, Kawamura M, Negoro Y, Araki N, Ishikawa H, Fujii T, Mitsuhashi N
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Journal Title
Jpn J Clin Oncol
Volume: 42
Pages: 807-812
Peer Reviewed
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[Presentation] A prospective clinical trial on tumor hypoxia imaging with 18F-misonidazole (F-MISO) positron emission tomography (PET)2011
Author(s)
Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, Tamura M, Koike R, Nishikawa T, Ishikawa K. Hosono M
Organizer
at the 53rd Annual Meeting of the American Society for Radiation Oncology
Place of Presentation
Miami Beach, FL, USA
Year and Date
20111002-06
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[Presentation] Tumor hypoxia and reoxygenation of human tumors imaged by 18F-misonidazole (F-MISO) positron emission tomography (PET)2011
Author(s)
Nishimura Y, Tachibana I, Shibata T, Kanamori S, Nakamatsu K, Koike R, Nishikawa T, Ishikawa K, Tamura M, Hosono M
Organizer
Presented at the 14th International Congress of Radiation Research
Place of Presentation
Warsaw, Poland(Abstract Book, pp124)
Year and Date
20110828-0901
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