2012 Fiscal Year Final Research Report
Experimental evaluation of a silk fibroin-coated vascular prosthesis
| Project/Area Number |
22591398
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYATA Tetsurou 東京大学, 医学部附属病院, 准教授 (70190791)
KOYAMA Hiroyuki 東京大学, 医学部附属病院, 特任准教授 (10241994)
OKAMOTO Hiroyuki 東京大学, 医学部附属病院, 特任講師 (60348266)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ASAKURA Tetsuo 東京農工大学, 共生科学技術研究科, 教授 (30139208)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 血管外科学 / 人工血管 |
|---|
| Research Abstract |
Polyester vascular grafts coated with silk fibroin or gelatin were implanted in the abdominal aorta and common carotid arteries of dogs. In contrast to gelatin-coated grafts, silk fibroin-coated grafts had less collagenous intimal layer with endothelial-like cells. These findings suggest that silk fibroin-coated graft might provide excellent patency of small-diameter vascular graft.
|
